The RasGAP N-terminal Fragment Generated by Caspase Cleavage Protects Cells in a Ras/PI3K/Akt-dependent Manner That Does Not Rely on NFκB Activation
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Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathwaysA WXW motif is required for the anticancer activity of the TAT-RasGAP317-326 peptideAssessment of the chemosensitizing activity of TAT-RasGAP317-326 in childhood cancersRas GTPase-activating protein binds to Akt and is required for its activationPartial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions.RasGAP-derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes.Impaired Akt activity down-modulation, caspase-3 activation, and apoptosis in cells expressing a caspase-resistant mutant of RasGAP at position 157Role of mTOR, Bad, and Survivin in RasGAP Fragment N-Mediated Cell ProtectionThe dark side of Ras: regulation of apoptosis.RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3.Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathwayRasGAP-derived peptide GAP159 enhances cisplatin-induced cytotoxicity and apoptosis in HCT116 cells.Vital functions for lethal caspases.Caspase-3 protects stressed organs against cell deathDephosphorylation and mitochondrial translocation of cofilin sensitizes human leukemia cells to cerulenin-induced apoptosis via the ROCK1/Akt/JNK signaling pathwayExpression of the NH(2)-terminal fragment of RasGAP in pancreatic beta-cells increases their resistance to stresses and protects mice from diabetes.High-density lipoprotein, beta cells, and diabetes .Apoptotic Caspases in Promoting Cancer: Implications from Their Roles in Development and Tissue Homeostasis.Fragment N2, a caspase-3-generated RasGAP fragment, inhibits breast cancer metastatic progression.Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils.Expression of an uncleavable N-terminal RasGAP fragment in insulin-secreting cells increases their resistance toward apoptotic stimuli without affecting their glucose-induced insulin secretion.2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process.Allelic imbalance and altered expression of genes in chromosome 2q11-2q16 from rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts.The caspase-3/p120 RasGAP stress-sensing module reduces liver cancer incidence but does not affect overall survival in gamma-irradiated and carcinogen-treated mice.Use of a peptide enhancing the ability of radiation therapy to kill cancer cells: a patent evaluation of WO2012016918.
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The RasGAP N-terminal Fragment Generated by Caspase Cleavage Protects Cells in a Ras/PI3K/Akt-dependent Manner That Does Not Rely on NFκB Activation
description
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
im Februar 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published in Journal of Biological Chemistry
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в лютому 2002
@uk
name
The RasGAP N-terminal Fragment ...... es Not Rely on NFκB Activation
@en
The RasGAP N-terminal Fragment ...... es Not Rely on NFκB Activation
@nl
type
label
The RasGAP N-terminal Fragment ...... es Not Rely on NFκB Activation
@en
The RasGAP N-terminal Fragment ...... es Not Rely on NFκB Activation
@nl
prefLabel
The RasGAP N-terminal Fragment ...... es Not Rely on NFκB Activation
@en
The RasGAP N-terminal Fragment ...... es Not Rely on NFκB Activation
@nl
P2860
P356
P1476
The RasGAP N-terminal Fragment ...... es Not Rely on NFκB Activation
@en
P2093
Jiang-Yan Yang
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P304
14641-14646
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10.1074/JBC.M111540200
P407
P577
2002-02-14T00:00:00Z