The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage.
about
An overview of Cdk1-controlled targets and processesImplication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage responseLimited TTP supply affects telomere length regulation in a telomerase-independent fashionSystematic quantification of gene interactions by phenotypic array analysisDNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.The protein kinase Snf1 is required for tolerance to the ribonucleotide reductase inhibitor hydroxyureaInhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme.Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae.Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Small Subunit Localization in Response to Iron Deficiency.Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex.Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae.Sen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae.Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.Linking DNA replication checkpoint to MBF cell-cycle transcription reveals a distinct class of G1/S genes.Tel1 kinase and subtelomere-bound Tbf1 mediate preferential elongation of short telomeres by telomerase in yeast.Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit.Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathwaysATR-like kinase Mec1 facilitates both chromatin accessibility at DNA replication forks and replication fork progression during replication stress.UV induced ubiquitination of the yeast Rad4-Rad23 complex promotes survival by regulating cellular dNTP pools.Identification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes.Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cellsNFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage responseHyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.Limiting amounts of budding yeast Rad53 S-phase checkpoint activity results in increased resistance to DNA alkylation damageSensing of replication stress and Mec1 activation act through two independent pathways involving the 9-1-1 complex and DNA polymerase εIxr1 is required for the expression of the ribonucleotide reductase Rnr1 and maintenance of dNTP poolsAssessment of the biological pathways targeted by isocyanate using N-succinimidyl N-methylcarbamate in budding yeast Saccharomyces cerevisiaeThe Schizosaccharomyces pombe replication inhibitor Spd1 regulates ribonucleotide reductase activity and dNTPs by binding to the large Cdc22 subunitThe subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence.Identification of phosphorylation sites on the yeast ribonucleotide reductase inhibitor Sml1.The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombeExcess single-stranded DNA inhibits meiotic double-strand break repair.Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunitYeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrationsNormally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variantDomain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae.
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P2860
The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage.
description
2001 nî lūn-bûn
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2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The ribonucleotide reductase i ...... and in response to DNA damage
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The ribonucleotide reductase i ...... and in response to DNA damage.
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The ribonucleotide reductase i ...... and in response to DNA damage.
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The ribonucleotide reductase i ...... and in response to DNA damage
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The ribonucleotide reductase i ...... and in response to DNA damage.
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The ribonucleotide reductase i ...... and in response to DNA damage.
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The ribonucleotide reductase i ...... and in response to DNA damage
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The ribonucleotide reductase i ...... and in response to DNA damage.
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The ribonucleotide reductase i ...... and in response to DNA damage.
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P2093
P2860
P356
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The ribonucleotide reductase i ...... and in response to DNA damage.
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P2093
P2860
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10.1093/EMBOJ/20.13.3544
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P577
2001-07-01T00:00:00Z