Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
about
Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbetaComparative protein structure modeling by iterative alignment, model building and model assessmentMutations in the RUNX2 gene in patients with cleidocranial dysplasiaRunx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancerDimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradationMutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunitIdentification of the regions involved in DNA binding by the mouse PEBP2alpha protein.Structure and Biophysics of CBFβ/RUNX and Its Translocation Products.MODBASE, a database of annotated comparative protein structure modelsOverview of protein structural and functional folds.Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles.A mutation in the S-switch region of the Runt domain alters the dynamics of an allosteric network responsible for CBFbeta regulation.Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF.Core binding factor β (CBFβ) is retained in the midbody during cytokinesisAuto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription.CBFβ and the leukemogenic fusion protein CBFβ-SMMHC associate with mitotic chromosomes to epigenetically regulate ribosomal genesAML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.Runx3 knockouts and stomach cancerRUNX1 mutations in clonal myeloid disorders: from conventional cytogenetics to next generation sequencing, a story 40 years in the makingOncogenic potential of the RUNX gene family: 'overview'.Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia.RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.The Runt domain of AML1 (RUNX1) binds a sequence-conserved RNA motif that mimics a DNA element.Transcriptional dysregulation during myeloid transformation in AML.Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia demonstrates novel genotype-phenotype correlations.New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.Solution structure of a DNA mimicking motif of an RNA aptamer against transcription factor AML1 Runt domain.Protein dynamics and function from solution state NMR spectroscopy.Filamin A-bound PEBP2beta/CBFbeta is retained in the cytoplasm and prevented from functioning as a partner of the Runx1 transcription factor.Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-caseinEnergetic contribution of residues in the Runx1 Runt domain to DNA binding.AML1B transcriptional repressor function is impaired by the Flt3-internal tandem duplication.Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid leukaemia 1/runt-related transcription factor 1, detected in acute myeloblastic leukaemia and myelodysplastic syndrome.Conjugation of two RNA aptamers improves binding affinity to AML1 Runt domain.Novel Mutation of the RUNX2 Gene in Patients with Cleidocranial Dysplasia.Characterisation of an aptamer against the Runt domain of AML1 (RUNX1) by NMR and mutational analyses.Energetic and functional contribution of residues in the core binding factor beta (CBFbeta ) subunit to heterodimerization with CBFalpha.Biophysical characterization of interactions between the core binding factor alpha and beta subunits and DNA.Mutations of the AML1 gene in acute myeloid leukemia of FAB types M0 and M7.
P2860
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P2860
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
@ast
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
@en
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
@nl
type
label
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
@ast
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
@en
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
@nl
prefLabel
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
@ast
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
@en
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
@nl
P2093
P356
P1476
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain
@en
P2093
K Shigesada
M H Werner
P356
10.1038/10658
P577
1999-07-01T00:00:00Z