The yeast Xrs2 complex functions in S phase checkpoint regulation
about
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointCritical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpointMre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activityStructure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signalingXrs2p regulates Mre11p translocation to the nucleus and plays a role in telomere elongation and meiotic recombination.Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae.Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication.MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae.Saccharomyces cerevisiae Mer2, Mei4 and Rec114 form a complex required for meiotic double-strand break formation.A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining.DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repairSaccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activitiesRole of RAD52 epistasis group genes in homologous recombination and double-strand break repairATR pathway is the primary pathway for activating G2/M checkpoint induction after re-replication.Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint.The genome-wide transcription response to telomerase deficiency in the thermotolerant yeast Hansenula polymorpha DL-1.Bacillus subtilis SbcC protein plays an important role in DNA inter-strand cross-link repairInterplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair.Cdk1-dependent regulation of the Mre11 complex couples DNA repair pathways to cell cycle progressionSgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends.Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA associationHistone deposition protein Asf1 maintains DNA replisome integrity and interacts with replication factor C.Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiaeAspergillus nidulans uvsBATR and scaANBS1 genes show genetic interactions during recovery from replication stress and DNA damageDelineation of WRN helicase function with EXO1 in the replicational stress responseSuppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae.The Mre11 complex is required for ATM activation and the G2/M checkpointA single unbranched S-phase DNA damage and replication fork blockage checkpoint pathway.MlaA, a hexameric ATPase linked to the Mre11 complex in archaeal genomes.The two different isoforms of the RSC chromatin remodeling complex play distinct roles in DNA damage responsesMultiple pathways promote short-sequence recombination in Saccharomyces cerevisiaeA genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damageThe generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complexA novel recombination pathway initiated by the Mre11/Rad50/Nbs1 complex eliminates palindromes during meiosis in Schizosaccharomyces pombe.Isolation and characterization of novel xrs2 mutations in Saccharomyces cerevisiae.Mutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activityGenetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway
P2860
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P2860
The yeast Xrs2 complex functions in S phase checkpoint regulation
description
2001 nî lūn-bûn
@nan
2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The yeast Xrs2 complex functions in S phase checkpoint regulation
@ast
The yeast Xrs2 complex functions in S phase checkpoint regulation
@en
The yeast Xrs2 complex functions in S phase checkpoint regulation
@nl
type
label
The yeast Xrs2 complex functions in S phase checkpoint regulation
@ast
The yeast Xrs2 complex functions in S phase checkpoint regulation
@en
The yeast Xrs2 complex functions in S phase checkpoint regulation
@nl
prefLabel
The yeast Xrs2 complex functions in S phase checkpoint regulation
@ast
The yeast Xrs2 complex functions in S phase checkpoint regulation
@en
The yeast Xrs2 complex functions in S phase checkpoint regulation
@nl
P2860
P356
P1433
P1476
The yeast Xrs2 complex functions in S phase checkpoint regulation
@en
P2093
D D'Amours
P2860
P304
P356
10.1101/GAD.208701
P407
P577
2001-09-01T00:00:00Z