Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice

Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice

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http://www.wikidata.org/entity/Q28362073

Q28362073

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Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-beta.Fibroblasts in fibrosis: novel roles and mediators Genetically manipulated mouse models of lung disease: potential and pitfalls Hypoxia induces myocyte-dependent COX-2 regulation in endothelial cells: role of VEGF Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways.PGE(2) inhibition of TGF-beta1-induced myofibroblast differentiation is Smad-independent but involves cell shape and adhesion-dependent signaling.Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-κB signaling pathway.Diminished prostaglandin E2 contributes to the apoptosis paradox in idiopathic pulmonary fibrosis Caveolin-1 regulates leucocyte behaviour in fibrotic lung disease Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis.Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin.Hypermethylation of PTGER2 confers prostaglandin E2 resistance in fibrotic fibroblasts from humans and mice.Role of myofibroblasts at the invasion front.Signal transduction pathway analysis in desmoid-type fibromatosis: transforming growth factor-β, COX2 and sex steroid receptors Lung myofibroblasts are characterized by down-regulated cyclooxygenase-2 and its main metabolite, prostaglandin E2.IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis Novel therapeutic approaches for pulmonary fibrosis.Prostaglandin (PG)E2 exhibits antifibrotic activity in vocal fold fibroblasts.Oncostatin M stimulates proliferation, induces collagen production and inhibits apoptosis of human lung fibroblasts IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins.Cyclooxygenase-2 signaling in vocal fold fibroblasts Severity of lung injury in cyclooxygenase-2-deficient mice is dependent on reduced prostaglandin E(2) production.Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease.Involvement of cyclooxygenase-2 and prostaglandins in the molecular pathogenesis of inflammatory lung diseases.Inhibitory effects of prostaglandin E2 on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma.Prostaglandin E2 and the pathogenesis of pulmonary fibrosis.Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts.Prostaglandin E₂ protects murine lungs from bleomycin-induced pulmonary fibrosis and lung dysfunction.Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis.Disorders of lung matrix remodeling.Prostaglandin E2 as an inhibitory modulator of fibrogenesis in human lung allografts Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis Macrophage recognition and phagocytosis of apoptotic fibroblasts is critically dependent on fibroblast-derived thrombospondin 1 and CD36.Fibroblasts isolated from normal lungs and those with idiopathic pulmonary fibrosis differ in interleukin-6/gp130-mediated cell signaling and proliferation Cytosolic phospholipase A₂: physiological function and role in disease.Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis Variable prostaglandin E2 resistance in fibroblasts from patients with usual interstitial pneumonia.

P2860

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P2860

Cyclooxygenase-2 deficiency results in a loss of the anti-proliferative response to transforming growth factor-beta in human fibrotic lung fibroblasts and promotes bleomycin-induced pulmonary fibrosis in mice

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http://www.wikidata.org/entity/Q28362073

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2001 nî lūn-bûn

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