about
In vitro selection, characterization, and application of deoxyribozymes that cleave RNATertiary contacts distant from the active site prime a ribozyme for catalysis.Existence of efficient divalent metal ion-catalyzed and inefficient divalent metal ion-independent channels in reactions catalyzed by a hammerhead ribozymeEnhanced product stability in the hammerhead ribozyme.Metal ions: supporting actors in the playbook of small ribozymes.Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations.Outersphere and innersphere coordinated metal ions in an aminoacyl-tRNA synthetase ribozymeBiochemical analysis of hatchet self-cleaving ribozymes.Biologically important reactions catalyzed by RNA molecules.Zinc-dependent cleavage in the catalytic core of the hammerhead ribozyme: evidence for a pH-dependent conformational changeThe hairpin ribozyme.Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn2+-only) behavior.Distinct reaction pathway promoted by non-divalent-metal cations in a tertiary stabilized hammerhead ribozyme.Metal-ion-dependent folding of a uranyl-specific DNAzyme: insight into function from fluorescence resonance energy transfer studies.Ribozyme catalysis: not different, just worse.Activity of HDV ribozymes to trans-cleave HCV RNAMapping L1 ligase ribozyme conformational switch.A versatile cis-blocking and trans-activation strategy for ribozyme characterization.Bridging the gap between theory and experiment to derive a detailed understanding of hammerhead ribozyme catalysis.Lewis acid catalysis of phosphoryl transfer from a copper(II)-NTP complex in a kinase ribozyme.Role of Mg2+ in hammerhead ribozyme catalysis from molecular simulationMetal ion specificities for folding and cleavage activity in the Schistosoma hammerhead ribozymeCation-specific structural accommodation within a catalytic RNA.Threshold occupancy and specific cation binding modes in the hammerhead ribozyme active site are required for active conformation.Activity, folding and Z-DNA formation of the 8-17 DNAzyme in the presence of monovalent ions.Importance in catalysis of a magnesium ion with very low affinity for a hammerhead ribozyme.Two distinct catalytic strategies in the hepatitis δ virus ribozyme cleavage reaction.Substrate specificity and kinetic framework of a DNAzyme with an expanded chemical repertoire: a putative RNaseA mimic that catalyzes RNA hydrolysis independent of a divalent metal cation.Divalent Metal Ion Activation of a Guanine General Base in the Hammerhead Ribozyme: Insights from Molecular Simulations.Heat capacity changes in RNA folding: application of perturbation theory to hammerhead ribozyme cold denaturation.Inverse thio effects in the hepatitis delta virus ribozyme reveal that the reaction pathway is controlled by metal ion charge density.Entropy-driven folding of an RNA helical junction: an isothermal titration calorimetric analysis of the hammerhead ribozyme.Characterization of a native hammerhead ribozyme derived from schistosomesArtificial tertiary motifs stabilize trans-cleaving hammerhead ribozymes under conditions of submillimolar divalent ions and high temperatures.An important role of G638 in the cis-cleavage reaction of the Neurospora VS ribozyme revealed by a novel nucleotide analog incorporation methodThe identity of the nucleophile substitution may influence metal interactions with the cleavage site of the minimal hammerhead ribozyme.Metal binding motif in the active site of the HDV ribozyme binds divalent and monovalent ions.Identification of the catalytic Mg²⁺ ion in the hepatitis delta virus ribozyme.Thio effects and an unconventional metal ion rescue in the genomic hepatitis delta virus ribozyme.The ionic environment determines ribozyme cleavage rate by modulation of nucleobase pK a
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The hammerhead cleavage reaction in monovalent cations
@ast
The hammerhead cleavage reaction in monovalent cations
@en
The hammerhead cleavage reaction in monovalent cations
@nl
type
label
The hammerhead cleavage reaction in monovalent cations
@ast
The hammerhead cleavage reaction in monovalent cations
@en
The hammerhead cleavage reaction in monovalent cations
@nl
prefLabel
The hammerhead cleavage reaction in monovalent cations
@ast
The hammerhead cleavage reaction in monovalent cations
@en
The hammerhead cleavage reaction in monovalent cations
@nl
P2860
P1433
P1476
The hammerhead cleavage reaction in monovalent cations
@en
P2093
P2860
P304
P356
10.1017/S1355838201002357
P407
P577
2001-04-01T00:00:00Z