Artificial tertiary motifs stabilize trans-cleaving hammerhead ribozymes under conditions of submillimolar divalent ions and high temperatures.
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Low-magnesium, trans-cleavage activity by type III, tertiary stabilized hammerhead ribozymes with stem 1 discontinuities.Antiviral Hammerhead Ribozymes Are Effective for Developing Transgenic Suppression of Chikungunya Virus in Aedes aegypti MosquitoesAutomated design of hammerhead ribozymes and validation by targeting the PABPN1 gene transcript.Hammerhead redux: does the new structure fit the old biochemical data?The hammerhead ribozyme: structure, catalysis, and gene regulationNucleotides that are essential but not conserved; a sufficient L-tryptophan site in RNA.Assembly and activation of a kinase ribozymeThe catalytic diversity of RNAs.Extraordinary rates of transition metal ion-mediated ribozyme catalysisTopological rearrangement yields structural stabilization and interhelical distance constraints in the Kin.46 self-phosphorylating ribozyme.A general design strategy for protein-responsive riboswitches in mammalian cells.Organelle trafficking of chimeric ribozymes and genetic manipulation of mitochondria.Conformational heterogeneity and the determinants of tertiary stabilization in the hammerhead ribozyme from Dolichopoda cave crickets.Folding of the hammerhead ribozyme: pyrrolo-cytosine fluorescence separates core folding from global folding and reveals a pH-dependent conformational change.Distinct reaction pathway promoted by non-divalent-metal cations in a tertiary stabilized hammerhead ribozyme.The importance of peripheral sequences in determining the metal selectivity of an in vitro-selected Co(2+) -dependent DNAzyme.In vitro evolution of distinct self-cleaving ribozymes in diverse environments.Minimal and extended hammerheads utilize a similar dynamic reaction mechanism for catalysis.Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.Robust suppression of HIV replication by intracellularly expressed reverse transcriptase aptamers is independent of ribozyme processing.A versatile cis-blocking and trans-activation strategy for ribozyme characterization.Two Active Site Divalent Ions in the Crystal Structure of the Hammerhead Ribozyme Bound to a Transition State AnalogueInhibition of miR-21 in glioma cells using catalytic nucleic acidsDirect selection for ribozyme cleavage activity in cellsCatalytic diversity of extended hammerhead ribozymesEvolution of ribozymes in the presence of a mineral surface.Improved design of hammerhead ribozyme for selective digestion of target RNA through recognition of site-specific adenosine-to-inosine RNA editing.Effects of the trinucleotide preceding the self-cleavage site on eggplant latent viroid hammerheads: differences in co- and post-transcriptional self-cleavage may explain the lack of trinucleotide AUC in most natural hammerheadsSelection of a novel class of RNA-RNA interaction motifs based on the ligase ribozyme with defined modular architecture.Long-range tertiary interactions in single hammerhead ribozymes bias motional sampling toward catalytically active conformationsTrans-cleaving hammerhead ribozymes with tertiary stabilizing motifs: in vitro and in vivo activity against a structured viroid RNAComparative single-turnover kinetic analyses of trans-cleaving hammerhead ribozymes with naturally derived non-conserved sequence motifs.Prediction of hammerhead ribozyme intracellular activity with the catalytic core fingerprint.RNA Structure Design Improves Activity and Specificity of trans-Splicing-Triggered Cell Death in a Suicide Gene Therapy Approach.
P2860
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P2860
Artificial tertiary motifs stabilize trans-cleaving hammerhead ribozymes under conditions of submillimolar divalent ions and high temperatures.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Artificial tertiary motifs sta ...... nt ions and high temperatures.
@en
type
label
Artificial tertiary motifs sta ...... nt ions and high temperatures.
@en
prefLabel
Artificial tertiary motifs sta ...... nt ions and high temperatures.
@en
P2093
P2860
P356
P1433
P1476
Artificial tertiary motifs sta ...... nt ions and high temperatures.
@en
P2093
Anastasia Khvorova
Donald H Burke
Manami Roychowdhury-Saha
Sumedha Jayasena
Vanvimon Saksmerprome
P2860
P304
P356
10.1261/RNA.7159504
P407
P577
2004-12-01T00:00:00Z