Crystal structures of a ddATP-, ddTTP-, ddCTP, and ddGTP- trapped ternary complex of Klentaq1: insights into nucleotide incorporation and selectivity
about
A unique error signature for human DNA polymerase nuSequence determination of nucleic acids containing 5-methylisocytosine and isoguanine: identification and insight into polymerase replication of the non-natural nucleobasesProcessive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations.Replication through an abasic DNA lesion: structural basis for adenine selectivitySolution Structure, Mechanism of Replication, and Optimization of an Unnatural Base PairStructural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymeraseLearning from directed evolution: Thermus aquaticus DNA polymerase mutants with translesion synthesis activityAmino Acid Templating Mechanisms in Selection of Nucleotides Opposite Abasic Sites by a Family A DNA PolymeraseStructures of KOD and 9°N DNA polymerases complexed with primer template duplexStructure and function of an RNA-reading thermostable DNA polymeraseBiochemical evidence for the requirement of Hoogsteen base pairing for replication by human DNA polymerase iotaConformational dynamics of Thermus aquaticus DNA polymerase I during catalysis.Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet.Optimization of an unnatural base pair toward natural-like replicationDiscrimination against purine-pyrimidine mispairs in the polymerase active site of DNA polymerase I: a structural explanation.Synthesis and evaluation of new spacers for use as dsDNA end-capsDependence of DNA polymerase replication rate on external forces: a model based on molecular dynamics simulationsUnnatural substrate repertoire of A, B, and X family DNA polymerases.Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase.The expanded genetic alphabet.Minor groove hydrogen bonds and the replication of unnatural base pairsPrechemistry nucleotide selection checkpoints in the reaction pathway of DNA polymerase I and roles of glu710 and tyr766.Fluorophore-quencher pair for monitoring protein motion.An error-prone family Y DNA polymerase (DinB homolog from Sulfolobus solfataricus) uses a 'steric gate' residue for discrimination against ribonucleotidesNeighbouring bases in template influence base-pairing of isoguanineIn Vivo Structure-Activity Relationships and Optimization of an Unnatural Base Pair for Replication in a Semi-Synthetic Organism.Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.dNTP-dependent conformational transitions in the fingers subdomain of Klentaq1 DNA polymerase: insights into the role of the "nucleotide-binding" state.A mechanism of nucleotide misincorporation during transcription due to template-strand misalignment.Selective transcription of an unnatural naphthyridine:imidazopyridopyrimidine base pair containing four hydrogen bonds with T7 RNA polymerase.A pre-equilibrium before nucleotide binding limits fingers subdomain closure by Klentaq1.The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases.Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.NTP-driven translocation by human RNA polymerase II.Crystal structures of ternary complexes of archaeal B-family DNA polymerases.
P2860
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P2860
Crystal structures of a ddATP-, ddTTP-, ddCTP, and ddGTP- trapped ternary complex of Klentaq1: insights into nucleotide incorporation and selectivity
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Crystal structures of a ddATP- ...... incorporation and selectivity
@ast
Crystal structures of a ddATP- ...... incorporation and selectivity
@en
Crystal structures of a ddATP- ...... incorporation and selectivity
@nl
type
label
Crystal structures of a ddATP- ...... incorporation and selectivity
@ast
Crystal structures of a ddATP- ...... incorporation and selectivity
@en
Crystal structures of a ddATP- ...... incorporation and selectivity
@nl
prefLabel
Crystal structures of a ddATP- ...... incorporation and selectivity
@ast
Crystal structures of a ddATP- ...... incorporation and selectivity
@en
Crystal structures of a ddATP- ...... incorporation and selectivity
@nl
P2860
P356
P1433
P1476
Crystal structures of a ddATP- ...... incorporation and selectivity
@en
P2860
P304
P356
10.1110/PS.250101
P407
P577
2001-06-01T00:00:00Z