Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo - Wikidata - wikimedia - TriplyDB

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

http://www.wikidata.org/entity/Q28368373

about

Apoptosis inducing effect of plumbagin on colonic cancer cells depends on expression of COX-2 The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3 Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs The selectivity of protein kinase inhibitors: a further update Grb2-SH3 ligand inhibits the growth of HER2+ cancer cells and has antitumor effects in human cancer xenografts alone and in combination with docetaxel Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure Modulating sensitivity to drug-induced apoptosis: the future for chemotherapy?Finding the needle in the haystack: why high-throughput screening is good for your health.Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activation.Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expression Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6 Phase I pharmacokinetic and pharmacodynamic study of the oral, small-molecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth Biophytum sensitivum (L.) DC inhibits tumor cell invasion and metastasis through a mechanism involving regulation of MMPs, prolyl hydroxylase, lysyl oxidase, nm23, ERK-1, ERK-2, STAT-1, and proinflammatory cytokine gene expression in metastatic lung The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition Specificity and mechanism of action of some commonly used protein kinase inhibitors Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia EGCG, a major component of green tea, inhibits tumour growth by inhibiting VEGF induction in human colon carcinoma cells Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial Cross-talk between signalling pathways and the multidrug resistant protein MDR-1 A dynamical systems model for combinatorial cancer therapy enhances oncolytic adenovirus efficacy by MEK-inhibition Inhibition of transforming growth factor-activated kinase 1 (TAK1) blocks and reverses epithelial to mesenchymal transition of mesothelial cells BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner The protein kinase TPL2 is essential for ERK1/ERK2 activation and cytokine gene expression in airway epithelial cells exposed to pathogen-associated molecular patterns (PAMPs)BRAF mutation predicts sensitivity to MEK inhibition Protein kinases--the major drug targets of the twenty-first century?

P2860

Q21560840-8EEA3058-653D-438D-AF55-4ED485AB4C37 Q21629049-08148053-623C-40E7-9E51-AB18A3D4388F Q24294827-FA863443-A611-4C40-879F-0CD0CD2E8A89 Q24294914-99F3E3F2-E8A7-438E-B233-08ED7CCC9882 Q24298749-1235A18A-1CE2-428B-B35A-4093F5E49578 Q24300649-DE664660-CC0B-483C-AF59-C57601C8B9E7 Q24301036-B83FD402-0800-465E-B953-F8B4E5D46AAF Q24303684-F1405D2F-6CFC-470D-BF93-0796899E0D2E Q24303940-B69E46DF-A518-469B-B2F8-20A37012BC70 Q24528133-54F46E49-56D1-4D9E-AB34-8F67F64535AD Q24528134-49D46ADC-25D3-42B9-A836-C974E63690D0 Q24530650-69ACC187-E980-42D2-903C-7385CE948F67 Q24533515-E2A620EC-AB47-4E94-9011-A9CC71F196C7 Q24535599-CDDDE09C-E84D-44F6-9FF6-E6E46AF56B35 Q24539187-66301ECD-B093-4DDB-B8FE-D7FD10ED8313 Q24654622-E77AD3C5-E84E-40DB-9792-80039C51A03A Q24658331-59AFDDF2-38C9-470C-B1CC-1E57F02FA761 Q24673616-5AFBD956-D073-4618-873B-4F42F02FF469 Q24797025-6D86C2F8-9C7E-4647-BA8B-BF0115DC382A Q24801341-47FC97AC-98CA-433F-B9D2-9C9BADA272DA Q24802613-9DE2EA10-1D6D-4137-AF70-AB5BC9F9BDC1 Q24805089-A6F16EBB-4C1A-483A-9726-218ED2D7D9F0 Q24816886-397EFDFF-87BC-438E-8A3E-743354C1C574 Q25257709-08B43B66-8E8C-4670-9D1A-5F652137FA8A Q27675436-9C6DE5D6-1A91-483D-BE64-60F76A37B064 Q27851426-D42C0ED2-ABF2-4CFB-A0F2-00694F7ACFDE Q28211693-EBC190D2-1C58-4435-B28D-B0A0812D0A1D Q28269683-9367A081-A5BD-4D6B-83D7-382320B3821D Q28301955-B3435445-65DF-4718-B47B-F4709883BFC5 Q28344791-31663E91-1F1A-421F-A8C8-22EBD2CC6519 Q28354257-0808041F-4340-43AF-9583-88E0D186C627 Q28360903-A1C45283-BC22-4294-B5BC-821138BE7098 Q28361953-E4B8EABE-2902-43ED-AFE9-337E4B6DE976 Q28364226-441C09CF-C773-4392-AB75-A2D0D64B3181 Q28477181-1E9DBEB0-5B7E-4671-9C6A-0142AFCCFA5A Q28481277-7D8FB4C4-26BA-4180-9011-E9E86FA57522 Q28481390-55A45DD9-1B4C-420F-999D-5DA3BE128737 Q28488321-6BA12CDC-E15A-4882-9C7A-1D8495225578 Q29614281-2ED585DC-47EF-4F4D-8F1F-CFA066C81BC7 Q29615339-604C7A2B-6A4A-4EA1-BB25-C1E6EC015659

P2860

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

http://www.wikidata.org/entity/Q28368373

description

1999 nî lūn-bûn

@nan

1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

name

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

@ast

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

@en

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

@nl

type

label

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

@ast

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

@en

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

@nl

prefLabel

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

@ast

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

@en

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

@nl

P1433

Q28368373-72EB6CA4-0E82-4E01-8B55-437184CEE768

P1476

Q28368373-7C20F829-7682-4D60-A551-DD88A96ED428

P2093

Q28368373-4B723AEB-676A-4587-993C-0C50670FA39F

Q28368373-5ABBC9B8-ADF5-44A2-9BF1-FBF89BC02255

Q28368373-6743973A-F31D-4E08-9B42-DCE65BDE68F1

Q28368373-678BF502-0084-41F7-9ED1-9BB39FCE817C

Q28368373-6FBBD1F2-0B46-4D08-87C4-0EB881C5A391

Q28368373-7B9DF863-5289-4E70-8C01-E3A35EB5BA58

Q28368373-9CC12F7E-6212-4D45-B4A5-8CB29A3A7971

Q28368373-A06370D3-BB16-4316-9309-2AB6E52EAF96

Q28368373-BEB52EF3-82F2-44DA-BDCC-6D8F0AF6F5B8

Q28368373-D50C1713-634A-4A73-9A75-D8353AABA545

P2888

Q28368373-1B04FF4F-141A-4D8A-BD04-DDD776D17377

P304

Q28368373-06FBDB6D-5344-4EFA-A10D-BF4C956A158E

P31

Q28368373-A30D20DA-FA54-4646-BF85-34FB95DDB455

P3181

Q28368373-DF489F28-C884-4037-89A4-2694AA001F4F

P356

Q28368373-2A8EF423-0FE4-484B-AE80-17C7A541417E

P407

Q28368373-335E070C-5E46-403C-A7C5-B1B81C74A2FA

P433

Q28368373-71BAA84F-1B39-4461-B818-541A25D20E83

P478

Q28368373-22174F42-816A-4705-8225-E75C9AB82D21

P50

Q28368373-A4648781-D359-411C-B500-6C37AD3DB354

P577

Q28368373-0BF6E348-1971-4942-A30F-357F743EB671

P698

Q28368373-8348AAD6-1882-4E7A-B863-E0149A01FAAA

P3181

P356

P1433

Nature Medicine

P1476

Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo

@en

P2093

Barrett SD

http://www.w3.org/2001/XMLSchema#string

Bridges A

http://www.w3.org/2001/XMLSchema#string

Dudley DT

http://www.w3.org/2001/XMLSchema#string

Gowan RC

http://www.w3.org/2001/XMLSchema#string

Herrera R

http://www.w3.org/2001/XMLSchema#string

Leopold WR

http://www.w3.org/2001/XMLSchema#string

Przybranowski S

http://www.w3.org/2001/XMLSchema#string

Sebolt-Leopold JS

http://www.w3.org/2001/XMLSchema#string

Tecle H

http://www.w3.org/2001/XMLSchema#string

Van Becelaere K

http://www.w3.org/2001/XMLSchema#string

P2888

P304

810-816

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2339054

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/10533

http://www.w3.org/2001/XMLSchema#string

P407

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

5

http://www.w3.org/2001/XMLSchema#string

P50

Alan R. Saltiel

P577

1999-07-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

10395327

http://www.w3.org/2001/XMLSchema#string