Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2 - Wikidata - wikimedia - TriplyDB

Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2

Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2

http://www.wikidata.org/entity/Q28382872

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p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level Does Nrf2 contribute to p53-mediated control of cell survival and death?Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention Antioxidant responses and cellular adjustments to oxidative stress The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage Hydrogen peroxide sensing, signaling and regulation of transcription factors Regulation of Drosophila metamorphosis by xenobiotic response regulators Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2 Multiple roles of Nrf2-Keap1 signaling: regulation of development and xenobiotic response using distinct mechanisms PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria Stress-activated cap'n'collar transcription factors in aging and human disease Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV Cytoprotection "gone astray": Nrf2 and its role in cancer The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders Mechanism of chemical activation of Nrf2 Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for hypoxic preconditioning-mediated delayed cardioprotection Prospective type 1 and type 2 disulfides of Keap1 protein.Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response.Non-thermal plasma activates human keratinocytes by stimulation of antioxidant and phase II pathways.Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differentiation.The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2.Hydrogen peroxide responsive miR153 targets Nrf2/ARE cytoprotection in paraquat induced dopaminergic neurotoxicity.Keap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liver.Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis.Chemistry of the cysteine sensors in Kelch-like ECH-associated protein 1 Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation.

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Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2

http://www.wikidata.org/entity/Q28382872

description

2007 nî lūn-bûn

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2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Keap1 controls postinduction r ...... corting nuclear export of Nrf2

@ast

Keap1 controls postinduction r ...... corting nuclear export of Nrf2

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Keap1 controls postinduction r ...... corting nuclear export of Nrf2

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type

label

Keap1 controls postinduction r ...... corting nuclear export of Nrf2

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Keap1 controls postinduction r ...... corting nuclear export of Nrf2

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Keap1 controls postinduction r ...... corting nuclear export of Nrf2

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Keap1 controls postinduction r ...... corting nuclear export of Nrf2

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Keap1 controls postinduction r ...... corting nuclear export of Nrf2

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Keap1 controls postinduction r ...... corting nuclear export of Nrf2

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Molecular and Cellular Biology

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Keap1 controls postinduction r ...... corting nuclear export of Nrf2

@en

P2093

Donna D Zhang

http://www.w3.org/2001/XMLSchema#string

Jefferson Y Chan

http://www.w3.org/2001/XMLSchema#string

Shirley Zhang

http://www.w3.org/2001/XMLSchema#string

Zheng Sun

http://www.w3.org/2001/XMLSchema#string

P2860

Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function

Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum

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6334-49

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scholarly article

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2315055

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10.1128/MCB.00630-07

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18

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27

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2007-09-01T00:00:00Z

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17636022

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2099624

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