Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF - Wikidata - wikimedia - TriplyDB

Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF

Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF

http://www.wikidata.org/entity/Q28474973

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A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy Epilepsy related to developmental tumors and malformations of cortical development The dynamic nature of the kinome Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers The metabolic basis of kidney cancer Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer.RAS oncogenes: weaving a tumorigenic web Activation of β-catenin by oncogenic PIK3CA and EGFR promotes resistance to glucose deprivation by inducing a strong antioxidant response Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation.Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth AMPK as a metabolic tumor suppressor: control of metabolism and cell growth.Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression.Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer.BRAFV600E negatively regulates the AKT pathway in melanoma cell lines.Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway.Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation.A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth NUAK2: an emerging acral melanoma oncogene Protein kinase A contributes to the negative control of Snf1 protein kinase in Saccharomyces cerevisiae.LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.BRAF V600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells.LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma Hepatocyte polarity Monitoring targeted therapy using dual-energy CT: semi-automatic RECIST plus supplementary functional information by quantifying iodine uptake of melanoma metastases.BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma.Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis.Dysregulation of mTOR activity through LKB1 inactivation.Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation.Targeting the LKB1 tumor suppressor.Molecular pathogenesis of pancreatic cancer and clinical perspectives.Current and future intratumoral targeted treatment for pancreatic cancer.LKB1 Tumor Suppressor: Therapeutic Opportunities Knock when LKB1 Is Inactivated.Effects of RAL signal transduction in KRAS- and BRAF-mutated cells and prognostic potential of the RAL signature in colorectal cancer

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P2860

Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF

http://www.wikidata.org/entity/Q28474973

description

2009 nî lūn-bûn

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2009 թուականին հրատարակուած գիտական յօդուած

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2009 թվականին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Uncoupling of the LKB1-AMPKalp ...... wth factors and oncogenic BRAF

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Uncoupling of the LKB1-AMPKalp ...... wth factors and oncogenic BRAF

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Uncoupling of the LKB1-AMPKalp ...... wth factors and oncogenic BRAF

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Uncoupling of the LKB1-AMPKalp ...... wth factors and oncogenic BRAF

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Uncoupling of the LKB1-AMPKalp ...... wth factors and oncogenic BRAF

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Uncoupling of the LKB1-AMPKalp ...... wth factors and oncogenic BRAF

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Uncoupling of the LKB1-AMPKalp ...... wth factors and oncogenic BRAF

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Uncoupling of the LKB1-AMPKalp ...... wth factors and oncogenic BRAF

@en

Uncoupling of the LKB1-AMPKalp ...... wth factors and oncogenic BRAF

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JOURNAL.PONE.0004771

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Uncoupling of the LKB1-AMPKalp ...... wth factors and oncogenic BRAF

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Francesc Canals

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Glenn Merlino

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Núria Colomé

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P2860

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

The LKB1 tumor suppressor negatively regulates mTOR signaling

Analysis of the LKB1-STRAD-MO25 complex

The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma

Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome

LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

LKB1 modulates lung cancer differentiation and metastasis

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Rosaura Esteve-Puig

Juan Angel Recio

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24189366

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2651576

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