Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome
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Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeActivation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADA mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradationStructure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activationAmino acids as regulators of gene expressionTuning a Three-Component Reaction For Trapping Kinase Substrate ComplexesIdentification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAFIonizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366Feeding and Fasting Signals Converge on the LKB1-SIK3 Pathway to Regulate Lipid Metabolism in DrosophilaLKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selectionATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROSLKB1 is required for adiponectin-mediated modulation of AMPK-S6K axis and inhibition of migration and invasion of breast cancer cellsMetastasis suppression by adiponectin: LKB1 rises up to the challenge.Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) miceLKB1, the multitasking tumour suppressor kinaseCyclin D1 Restrains Oncogene-Induced Autophagy by Regulating the AMPK-LKB1 Signaling Axis.Phosphorylation of ASPP2 by RAS/MAPK pathway is critical for its full pro-apoptotic functionLKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation.Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins.Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary TumorigenesisMechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.Analysis for phenotype of HNPCC in China.Intact LKB1 activity is required for survival of dormant ovarian cancer spheroidsIdentification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis.Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.Dysregulation of mTOR activity through LKB1 inactivation.Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways.Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations.The LKB1 complex-AMPK pathway: the tree that hides the forestLKB1 and AMP-activated protein kinase: regulators of cell polarity.Identification of protein phosphorylation sites by a combination of mass spectrometry and solid phase Edman sequencing.Crystallization and preliminary crystallographic analysis of the chimeric protein LKB1-14-3-3ζ.Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta.Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis
P2860
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P2860
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome
description
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
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im März 2002 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2002/03/01)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/03/01)
@nl
наукова стаття, опублікована в березні 2002
@uk
مقالة علمية (نشرت في مارس 2002)
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name
Identification and characteriz ...... Peutz-Jeghers cancer syndrome
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Identification and characteriz ...... Peutz-Jeghers cancer syndrome
@en
Identification and characteriz ...... Peutz-Jeghers cancer syndrome
@nl
type
label
Identification and characteriz ...... Peutz-Jeghers cancer syndrome
@ast
Identification and characteriz ...... Peutz-Jeghers cancer syndrome
@en
Identification and characteriz ...... Peutz-Jeghers cancer syndrome
@nl
prefLabel
Identification and characteriz ...... Peutz-Jeghers cancer syndrome
@ast
Identification and characteriz ...... Peutz-Jeghers cancer syndrome
@en
Identification and characteriz ...... Peutz-Jeghers cancer syndrome
@nl
P2093
P2860
P1433
P1476
Identification and characteriz ...... Peutz-Jeghers cancer syndrome
@en
P2093
Agnieszka Kieloch
Gopal P Sapkota
Jérôme Boudeau
Maria Deak
Nick Morrice
P2860
P304
P356
10.1042/0264-6021:3620481
P407
P577
2002-03-01T00:00:00Z