The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits - Wikidata - wikimedia - TriplyDB

The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits

The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits

http://www.wikidata.org/entity/Q28475744

about

Principles of agonist recognition in Cys-loop receptors Phylogenomics of ligand-gated ion channels predicts monepantel effect HelmCoP: an online resource for helminth functional genomics and drug and vaccine targets prioritization An extensive comparison of the effect of anthelmintic classes on diverse nematodes Functional characterization of a novel family of acetylcholine-gated chloride channels in Schistosoma mansoni Functional Characterization of a Novel Class of Morantel-Sensitive Acetylcholine Receptors in Nematodes Curiouser and Curiouser: The Macrocyclic Lactone, Abamectin, Is also a Potent Inhibitor of Pyrantel/Tribendimidine Nicotinic Acetylcholine Receptors of Gastro-Intestinal Worms Recent Duplication and Functional Divergence in Parasitic Nematode Levamisole-Sensitive Acetylcholine Receptors Expression of nicotinic acetylcholine receptor subunits from parasitic nematodes in Caenorhabditis elegans.Levamisole and ryanodine receptors. I: A contraction study in Ascaris suum Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit.The Conqueror Worm: recent advances with cholinergic anthelmintics and techniques excite research for better therapeutic drugs.Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions.Anthelmintic resistance: markers for resistance, or susceptibility?Ion channels and drug transporters as targets for anthelmintics.Tribendimidine: mode of action and nAChR subtype selectivity in Ascaris and Oesophagostomum Functional reconstitution of Haemonchus contortus acetylcholine receptors in Xenopus oocytes provides mechanistic insights into levamisole resistance.Expression of five acetylcholine receptor subunit genes in Brugia malayi adult worms Selective effect of the anthelmintic bephenium on Haemonchus contortus levamisole-sensitive acetylcholine receptors.Levamisole receptors: a second awakening.Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo MicroRNAs of Toxocara canis and their predicted functional roles.Acetylcholine receptor subunit and P-glycoprotein transcription patterns in levamisole-susceptible and -resistant Haemonchus contortus.Parasite neuropeptide biology: Seeding rational drug target selection?Ion channels and receptor as targets for the control of parasitic nematodes.Investigation of acetylcholine receptor diversity in a nematode parasite leads to characterization of tribendimidine- and derquantel-sensitive nAChRs.Transcriptomic evaluation of the nicotinic acetylcholine receptor pathway in levamisole-resistant and -sensitive Oesophagostomum dentatum.Discovery and development of veterinary antiparasitic drugs: past, present and future.Current drug targets for helminthic diseases.Present-day anthelmintics and perspectives on future new targets.The evolution of pentameric ligand-gated ion-channels and the changing family of anthelmintic drug targets.Polymorphism in ion channel genes of Dirofilaria immitis: Relevant knowledge for future anthelmintic drug design.Acetylcholinesterase and Nicotinic Acetylcholine Receptors in Schistosomes and Other Parasitic Helminths.Transient effects of levamisole on Brugia malayi microfilariae.microRNAs: a role in drug resistance in parasitic nematodes?Reduction in mRNA and protein expression of a nicotinic acetylcholine receptor α8 subunit is associated with resistance to imidacloprid in the brown planthopper, Nilaparvata lugens.Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species.

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P2860

The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits

http://www.wikidata.org/entity/Q28475744

description

2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

The nicotinic acetylcholine re ...... ression levels of two subunits

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JOURNAL.PPAT.1000517

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The nicotinic acetylcholine re ...... ression levels of two subunits

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Adrian J Wolstenholme

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Alan P Robertson

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David B Sattelle

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Laurence Brown

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Sally M Williamson

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Tracey Williams

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P2860

Draft genome of the filarial nematode parasite Brugia malayi

Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm

A molecular evolutionary framework for the phylum Nematoda

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

Could control of soil-transmitted helminthic infection influence the HIV/AIDS pandemic.

Ultrastructure of somatic muscle cells in Ascaris lumbricoides. II. Intermuscular junctions, neuromuscular junctions, and glycogen stores.

Ascariasis is a zoonosis in denmark.

Ascaris and ascariasis.

Animal models of intestinal nematode infections of humans.

A new class of anthelmintics effective against drug-resistant nematodes.

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e1000517

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scholarly article

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2126834

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10.1371/JOURNAL.PPAT.1000517

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7

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5

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Richard J Martin

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2009-07-17T00:00:00Z

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26677134

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19609360

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