Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme
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Therapeutic interactions of autophagy with radiation and temozolomide in glioblastoma: evidence and issues to resolveA kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastomaDexamethasone reduces sensitivity to cisplatin by blunting p53-dependent cellular senescence in non-small cell lung cancerThe pharmacodynamics of the p53-Mdm2 targeting drug Nutlin: the role of gene-switching noiseIdentification of hub genes and regulatory factors of glioblastoma multiforme subgroups by RNA-seq data analysisMicroRNAs/TP53 feedback circuitry in glioblastoma multiformep53 Family and Cellular Stress Responses in Cancer.A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells.Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor.Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway.Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells.Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways.Nanoparticle-Mediated Target Delivery of TRAIL as Gene Therapy for GlioblastomaLong lasting MDM2/Translocator protein modulator: a new strategy for irreversible apoptosis of human glioblastoma cells.Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade gliomaUp-regulating telomerase and tumor suppressors: focusing on anti-aging interventions at the population level.Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cellsApoptosis therapy in cancer: the first single-molecule co-activating p53 and the translocator protein in glioblastoma.Discovery of PI-1840, a novel noncovalent and rapidly reversible proteasome inhibitor with anti-tumor activity.Nutlin-3, an Antagonist of MDM2, Enhances the Radiosensitivity of Esophageal Squamous Cancer with Wild-Type p53.Nutlin-3a selects for cells harbouring TP53 mutations.Genetic biomarkers of drug response for small-molecule therapeutics targeting the RTK/Ras/PI3K, p53 or Rb pathway in glioblastoma.The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancerThe failure in the stabilization of glioblastoma-derived cell lines: spontaneous in vitro senescence as the main culprit.Induction of DNA damage and p21-dependent senescence by Riccardin D is a novel mechanism contributing to its growth suppression in prostate cancer cells in vitro and in vivo.Combination treatment for glioblastoma cells with tumor necrosis factor-related apoptosis-inducing ligand and oncolytic adenovirus delta-24.Mdm2 antagonists induce apoptosis and synergize with cisplatin overcoming chemoresistance in TP53 wild-type ovarian cancer cells.An intrinsic DFF40/CAD endonuclease deficiency impairs oligonucleosomal DNA hydrolysis during caspase-dependent cell death: a common trait in human glioblastoma cells.Nutlin-3 enhances the bortezomib sensitivity of p53-defective cancer cells by inducing paraptosis.Nutlin-3a Nanodisks Induce p53 Stabilization and Apoptosis in a Subset of Cultured Glioblastoma CellsHBeAg-induced miR-106b promotes cell growth by targeting the retinoblastoma gene.Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways.Radioresistance of mesenchymal glioblastoma initiating cells correlates with patient outcome and is associated with activation of inflammatory program.PRMT5 as a druggable target for glioblastoma therapy.The role of stochastic gene switching in determining the pharmacodynamics of certain drugs: basic mechanisms.Topical nutlin-3a does not decrease photocarcinogenesis induced by simulated solar radiation in hairless mice.Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype.ATLANTIS - Attractor Landscape Analysis Toolbox for Cell Fate Discovery and Reprogramming.A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models.p53 and metabolism: from mechanism to therapeutics.
P2860
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P2860
Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Activation of p53 by nutlin-3a ...... human glioblastoma multiforme
@ast
Activation of p53 by nutlin-3a ...... human glioblastoma multiforme
@en
Activation of p53 by nutlin-3a ...... human glioblastoma multiforme
@nl
type
label
Activation of p53 by nutlin-3a ...... human glioblastoma multiforme
@ast
Activation of p53 by nutlin-3a ...... human glioblastoma multiforme
@en
Activation of p53 by nutlin-3a ...... human glioblastoma multiforme
@nl
prefLabel
Activation of p53 by nutlin-3a ...... human glioblastoma multiforme
@ast
Activation of p53 by nutlin-3a ...... human glioblastoma multiforme
@en
Activation of p53 by nutlin-3a ...... human glioblastoma multiforme
@nl
P2093
P2860
P50
P3181
P1433
P1476
Activation of p53 by nutlin-3a ...... human glioblastoma multiforme
@en
P2093
Fina Martínez-Soler
Juan-Jose Acebes
Llorenç Coll-Mulet
Ruth Villalonga-Planells
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0018588
P407
P577
2011-04-05T00:00:00Z