Patched1 regulates hedgehog signaling at the primary cilium
about
The Hedgehog protein familyThe Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complexThe dynamic cilium in human diseasesLive imaging of individual cell divisions in mouse neuroepithelium shows asymmetry in cilium formation and Sonic hedgehog responseEvc2 is a positive modulator of Hedgehog signalling that interacts with Evc at the cilia membrane and is also found in the nucleusBBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypesIncreased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neuronsInteraction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signallingThe Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formationNEK1 mutations cause short-rib polydactyly syndrome type majewskiRab10 associates with primary cilia and the exocyst complex in renal epithelial cells.The hedgehog receptor patched is involved in cholesterol transportPitchfork regulates primary cilia disassembly and left-right asymmetryThe output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteinsDisruption of Mks1 localization to the mother centriole causes cilia defects and developmental malformations in Meckel-Gruber syndromeArsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathwayGli-similar (Glis) Krüppel-like zinc finger proteins: insights into their physiological functions and critical roles in neonatal diabetes and cystic renal diseaseArsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effectorItraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonistsThe role of primary cilia in neuronal functionSignaling mechanisms regulating adult neural stem cells and neurogenesisStructure and function of mammalian ciliaTiming neurogenesis and differentiation: insights from quantitative clonal analyses of cerebellar granule cellsMicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signalingThe cilia-regulated proteasome and its role in the development of ciliopathies and cancerHedgehog Signaling in Pancreatic Fibrosis and CancerCilia in autophagy and cancerThe Roles of Hedgehog Signaling in Upper Lip FormationThe Role of Hedgehog Signaling in Tumor Induced Bone DiseaseIns and outs of GPCR signaling in primary ciliaCilia in vertebrate development and diseaseCrosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapyRab and Arf proteins in genetic diseasesThe primary cilium as a dual sensor of mechanochemical signals in chondrocytesCilia/Ift protein and motor -related bone diseases and mouse modelsCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyPrimary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengersCell cycle progression by the repression of primary cilia formation in proliferating cellsHedgehog signaling pathway and its targets for treatment in basal cell carcinomaDecoding the phosphorylation code in Hedgehog signal transduction
P2860
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P2860
Patched1 regulates hedgehog signaling at the primary cilium
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Patched1 regulates hedgehog signaling at the primary cilium
@ast
Patched1 regulates hedgehog signaling at the primary cilium
@en
type
label
Patched1 regulates hedgehog signaling at the primary cilium
@ast
Patched1 regulates hedgehog signaling at the primary cilium
@en
prefLabel
Patched1 regulates hedgehog signaling at the primary cilium
@ast
Patched1 regulates hedgehog signaling at the primary cilium
@en
P2093
P2860
P3181
P356
P1433
P1476
Patched1 regulates hedgehog signaling at the primary cilium
@en
P2093
P2860
P3181
P356
10.1126/SCIENCE.1139740
P407
P577
2007-07-20T00:00:00Z