c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
about
Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1The role of Src in solid tumorsSam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasisActin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary glandSrc tyrosine kinase phosphorylation of nuclear receptor HNF4α correlates with isoform-specific loss of HNF4α in human colon cancer.Disruption of Src Is Associated with Phenotypes Related to Williams-Beuren Syndrome and Altered Cellular Localization of TFII-I(1,2).Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells.Lactation failure in Src knockout mice is due to impaired secretory activation.C-Src and c-Yes are two unlikely partners of spermatogenesis and their roles in blood-testis barrier dynamics.Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland.Control of mammary tumor differentiation by SKI-606 (bosutinib).Regulated phosphorylation of a major UDP-glucuronosyltransferase isozyme by tyrosine kinases dictates endogenous substrate selection for detoxification.c-Jun N-terminal Kinase 2 Regulates Multiple Receptor Tyrosine Kinase Pathways in Mouse Mammary Tumor Growth and Metastasis.Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis.Mouse mammary tumor virus suppresses apoptosis of mammary epithelial cells through ITAM-mediated signaling.Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin β1.The extracellular matrix as an adhesion checkpoint for mammary epithelial function.Patterns of cell signaling pathway activation that characterize mammary development.Targeting Src in breast cancer.Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancerMeaningful prevention of breast cancer metastasis: candidate therapeutics, preclinical validation, and clinical trial concerns.KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor α positive breast cancer.Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway.The contribution of adhesion signaling to lactogenesis.SRC increases MYC mRNA expression in ER+ breast cancer via mRNA stabilization and inhibition of p53 function.Tyrosine Phosphorylation of the Pioneer Transcription Factor FoxA1 Promotes Activation of Estrogen Signaling.
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P2860
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
description
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
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im August 2005 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2005/08/25)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/08/25)
@nl
наукова стаття, опублікована в серпні 2005
@uk
مقالة علمية (نشرت في 25-8-2005)
@ar
name
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
@ast
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
@en
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
@nl
type
label
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
@ast
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
@en
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
@nl
prefLabel
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
@ast
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
@en
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
@nl
P2093
P2860
P356
P1433
P1476
c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling
@en
P2093
Harold Kim
Mike Laing
William Muller
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208718
P407
P577
2005-08-25T00:00:00Z
P5875
P6179
1003698243