Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy
about
Genetic counselling for hypertrophic cardiomyopathy: are we ready for it?Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motorCryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolutionMyofilament Calcium Sensitivity: Role in Regulation of In vivo Cardiac Contraction and RelaxationWhy Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardiumInterpreting cardiac muscle force-length dynamics using a novel functional modelEchocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathySexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy miceRescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes.The molecular genetic basis for hypertrophic cardiomyopathy.Experimental therapies in hypertrophic cardiomyopathyMolecular genetics and pathogenesis of hypertrophic cardiomyopathy.Hypertrophic cardiomyopathy: a heart in need of an energy bar?Ca-activation and stretch-activation in insect flight muscle.Elementary steps of the cross-bridge cycle in fast-twitch fiber types from rabbit skeletal muscles.The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model.Molecular mechanisms of inherited cardiomyopathies.Cardiac troponin I Pro82Ser variant induces diastolic dysfunction, blunts β-adrenergic response, and impairs myofilament cooperativityLong-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein.Mechanotransduction in cardiac myocytes.Two-state model of acto-myosin attachment-detachment predicts C-process of sinusoidal analysisCell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy.Kinetics and energetics of the crossbridge cycle.Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes.Use of thin filament reconstituted muscle fibres to probe the mechanism of force generation.Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backboneModulation of cardiac performance by motor protein gene transfer.Designing heart performance by gene transfer.Biomarkers of pathophysiology in hypertrophic cardiomyopathy: implications for clinical management and prognosis.Effects of cardiac myosin isoform variation on myofilament function and crossbridge kinetics in transgenic rabbitsHypertrophic cardiomyopathy: preclinical and early phenotype.How do mutations in contractile proteins cause the primary familial cardiomyopathies?Distribution of myosin attachment times predicted from viscoelastic mechanics of striated muscle.Nonlinear myofilament regulatory processes affect frequency-dependent muscle fiber stiffness.New Paradigms in Hypertrophic Cardiomyopathy: Insights from Genetics.Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.Troponin I phosphorylation enhances crossbridge kinetics during beta-adrenergic stimulation in rat cardiac tissue.An analysis of deformation-dependent electromechanical coupling in the mouse heart.Speckle tracking imaging in hypertrophic cardiomyopathy : A powerful tool in search of an unfavorable substrate?
P2860
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P2860
Altered crossbridge kinetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy
description
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im März 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/03/05)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/03/05)
@nl
наукова стаття, опублікована в березні 1999
@uk
научни чланак (објављен 1999/03/05)
@sr
name
Altered crossbridge kinetics i ...... al hypertrophic cardiomyopathy
@ast
Altered crossbridge kinetics i ...... al hypertrophic cardiomyopathy
@en
Altered crossbridge kinetics i ...... al hypertrophic cardiomyopathy
@nl
type
label
Altered crossbridge kinetics i ...... al hypertrophic cardiomyopathy
@ast
Altered crossbridge kinetics i ...... al hypertrophic cardiomyopathy
@en
Altered crossbridge kinetics i ...... al hypertrophic cardiomyopathy
@nl
prefLabel
Altered crossbridge kinetics i ...... al hypertrophic cardiomyopathy
@ast
Altered crossbridge kinetics i ...... al hypertrophic cardiomyopathy
@en
Altered crossbridge kinetics i ...... al hypertrophic cardiomyopathy
@nl
P2093
P3181
P356
P1433
P1476
Altered crossbridge kinetics i ...... al hypertrophic cardiomyopathy
@en
P2093
C. Seidman
D. Maughan
E. Blanchard
J. G. Seidman
M. LeWinter
P304
P3181
P356
10.1161/01.RES.84.4.475
P577
1999-03-05T00:00:00Z