Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation
about
Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosisEpileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytesImpaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberinTsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex.Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2-dependent manner.Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling.Biallelic TSC gene inactivation in tuberous sclerosis complexRapamycin for treating Tuberous sclerosis and Autism spectrum disordersNeurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex.The impact of coexisting genetic mutations on murine optic glioma biology.Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth.Mouse models of tuberous sclerosis complex.Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform NeurofibromaDNA methylation Landscape of body size variation in sheepPediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner.Altered Structural Brain Networks in Tuberous Sclerosis ComplexMechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation.Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function.The natural history and treatment of epilepsy in a murine model of tuberous sclerosis.Autophagy: regulation and role in disease.Animal models of focal cortical dysplasia and tuberous sclerosis complex: recent progress toward clinical applications.The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling.Catenin delta-1 (CTNND1) phosphorylation controls the mesenchymal to epithelial transition in astrocytic tumors.Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival.The neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent mannerMammalian target of rapamycin in spinal cord neurons mediates hypersensitivity induced by peripheral inflammation.The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord.Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formationLoss of GSK-3 Causes Abnormal Astrogenesis and Behavior in Mice.Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.Characteristics of abnormal diffusivity in normal-appearing white matter investigated with diffusion tensor MR imaging in tuberous sclerosis complex.RHEB1 expression in embryonic and postnatal mouse.RHEB1 insufficiency in aged male mice is associated with stress-induced seizures.
P2860
Q24670558-1B633AFA-D44C-44F9-99C9-FD2A7A7B3650Q28591888-08564807-7628-4331-8544-87C7FB89BDC7Q30459608-A86E11B6-3316-4960-8ED7-292720007B77Q30497818-1376FC08-1D06-4CF2-B6CB-5C94A85A670EQ30573030-CD4BFBE7-F181-4D35-AD45-8291485D24F6Q33591646-0735EC27-8C12-49F4-BDD9-EB962D52A9FBQ33724411-7A69A3E4-3D9A-4347-9D36-49B6881212CDQ33899858-76C1D3EB-64B7-47A2-B9FC-DEE29715716EQ34024856-73A9E99E-75E8-4335-8FF4-0C4D53687399Q35229380-FBB9602A-6E4F-4EBF-A8A9-325AA3C354B6Q35748464-5FAA9D37-BF39-42FC-B9C0-738675F6A812Q35788566-000BB1F8-F99C-4507-B50A-0A6804906D10Q35788976-F75ED5CB-2ABD-4BBA-A014-E899A7133E50Q35962483-B0572E9F-467C-40B3-B4AE-F14CC66117E1Q36070199-61530F66-4ED8-46F6-A429-F52B17BDF612Q36168356-2E7322C2-809E-45DA-BD0F-84DFA966679DQ36464991-7CFAA470-339D-4229-B5F5-77234B16C2D0Q36794363-B56D8B98-3DF6-40C5-BD63-04F0A198DA81Q36922578-CDF9A057-8B5E-428F-B1CD-7602057D9BD7Q37079765-C981CBDB-F6E0-4912-BFA5-53E69E542004Q37504256-25235010-02C0-435C-AE0C-B5B158C415DCQ37529825-CC892A15-EC7E-4FF0-B3C7-B0C9822655E0Q37598955-7D037D51-45A4-444B-A5EE-F5B95920D9A6Q37831801-8D0924A5-333D-4238-8A11-524DB9EC7898Q38752328-5DEF8082-EA48-4437-9773-D1169EB36143Q39658084-F4B87E88-791E-4901-BBAD-C54131A1B116Q41814702-5D0EF8C3-CB72-4BDE-82E4-4BFA276AA019Q41904089-73662D9D-5DA6-4AC4-B094-585CB92295A3Q41957358-CEBD5A2A-7887-48D7-84C0-C4FB67FDE6A6Q42572216-3B18DDE6-871E-44B6-A978-95A039AD702AQ43084661-5BAE4677-157F-429F-9D38-70588D5EFAB1Q46785716-18FEDDCB-DF3C-4AE4-ABDE-28855FB5C9CDQ46983617-A2D9AD3D-D55C-47F2-B3D1-7BDDDBE15166Q47569033-EF37E599-A42C-4EA7-A2A9-0BA6FD3D0983Q54146954-715CF33D-BB5F-42B5-ADFE-7D74AF760713
P2860
Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation
description
2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im August 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/08/01)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/08/01)
@nl
наукова стаття, опублікована в серпні 2004
@uk
مقالة علمية (نشرت في أغسطس 2004)
@ar
name
Loss of tuberous sclerosis com ...... astrocyte cell size regulation
@ast
Loss of tuberous sclerosis com ...... astrocyte cell size regulation
@en
Loss of tuberous sclerosis com ...... astrocyte cell size regulation
@nl
type
label
Loss of tuberous sclerosis com ...... astrocyte cell size regulation
@ast
Loss of tuberous sclerosis com ...... astrocyte cell size regulation
@en
Loss of tuberous sclerosis com ...... astrocyte cell size regulation
@nl
prefLabel
Loss of tuberous sclerosis com ...... astrocyte cell size regulation
@ast
Loss of tuberous sclerosis com ...... astrocyte cell size regulation
@en
Loss of tuberous sclerosis com ...... astrocyte cell size regulation
@nl
P2093
P2860
P356
P1433
P1476
Loss of tuberous sclerosis com ...... astrocyte cell size regulation
@en
P2093
Chia-Ling Gau
Danielle K Scheidenhelm
Erik J Uhlmann
Fuyuhiko Tamanoi
P2860
P304
P356
10.1002/GLIA.20036
P577
2004-08-01T00:00:00Z