Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex
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NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathwayP130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreadingDirect binding of p130(Cas) to the guanine nucleotide exchange factor C3GFocal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophyCytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinaseAssociation of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entryThe integrin alpha 7 cytoplasmic domain regulates cell migration, lamellipodia formation, and p130CAS/Crk couplingCas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton.Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas (Crk-associated substrate), promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substratep130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestrationEpidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeletonRequirement of Nck adaptors for actin dynamics and cell migration stimulated by platelet-derived growth factor B.CrkII induces serum response factor activation and cellular transformation through its function in Rho activation.The Crk signaling pathway contributes to the bombesin-induced activation of the small GTPase Rap1 in Swiss 3T3 cells.c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase.Integrin engagement, the actin cytoskeleton, and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1, but not for calcitonin-induced Erk1/2 phosphorylation.Regulation of c-SRC activity and function by the adapter protein CASCas mediates transcriptional activation of the serum response element by Src.The functional role of CrkII in actin cytoskeleton organization and mitogenesis.PR-39, a syndecan-inducing antimicrobial peptide, binds and affects p130(Cas).Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells.SRChing for the substrates of Src.G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways.Roles of protein tyrosine phosphatases in cell migration and adhesion.Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylationRegulation of cell contraction and membrane ruffling by distinct signals in migratory cells.The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signalingHyperosmotic stress induces rapid focal adhesion kinase phosphorylation at tyrosines 397 and 577. Role of Src family kinases and Rho family GTPases.Integrin-mediated signaling events in human endothelial cells.Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.Glucose stimulates the tyrosine phosphorylation of Crk-associated substrate in pancreatic beta-cells.Anchorage-independent phosphorylation of p130(Cas) protects lung adenocarcinoma cells from anoikis.Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-beta 1.Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation.Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate.Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1 - Crk signaling complex formation.Tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin does not require extracellular signal-regulated kinase activation in Swiss 3T3 cells stimulated by bombesin or platelet-derived growth factor.[D-Arg(1),D-Trp(5,7,9),Leu(11)]Substance P inhibits bombesin-induced mitogenic signal transduction mediated by both G(q) and G(12) in Swiss 3T3cells.Activity of Rap1 is regulated by bombesin, cell adhesion, and cell density in NIH3T3 fibroblasts.
P2860
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P2860
Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex
description
1997 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
@ast
im April 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/04/04)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/04/04)
@nl
наукова стаття, опублікована у квітні 1997
@uk
name
Tyrosine phosphorylation of p1 ...... ion of a p130(cas)-Crk complex
@ast
Tyrosine phosphorylation of p1 ...... ion of a p130(cas)-Crk complex
@en
Tyrosine phosphorylation of p1 ...... ion of a p130(cas)-Crk complex
@nl
type
label
Tyrosine phosphorylation of p1 ...... ion of a p130(cas)-Crk complex
@ast
Tyrosine phosphorylation of p1 ...... ion of a p130(cas)-Crk complex
@en
Tyrosine phosphorylation of p1 ...... ion of a p130(cas)-Crk complex
@nl
prefLabel
Tyrosine phosphorylation of p1 ...... ion of a p130(cas)-Crk complex
@ast
Tyrosine phosphorylation of p1 ...... ion of a p130(cas)-Crk complex
@en
Tyrosine phosphorylation of p1 ...... ion of a p130(cas)-Crk complex
@nl
P2860
P356
P1476
Tyrosine phosphorylation of p1 ...... ion of a p130(cas)-Crk complex
@en
P2093
A. Casamassima
E. Rozengurt
P2860
P304
P356
10.1074/JBC.272.14.9363
P407
P577
1997-04-04T00:00:00Z