Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate
about
Differential regulation of cell motility and invasion by FAKP130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migrationMolecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycleVery-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IVp130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestrationForce Sensing by Mechanical Extension of the Src Family Kinase Substrate p130CasIdentification of Novel Crk-associated Substrate (p130Cas) Variants with Functionally Distinct Focal Adhesion Kinase Binding ActivitiesBreast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas)Tyrosine phosphorylation within the SH3 domain regulates CAS subcellular localization, cell migration, and invasivenessDynamics and mechanism of p130Cas localization to focal adhesionsCooperative activation of Src family kinases by SH3 and SH2 ligands.Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3.BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signalingInvasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130CasSrc phosphorylates Cas on tyrosine 253 to promote migration of transformed cellsSynthesis of functional signaling domains by combinatorial polymerization of phosphorylation motifs.The docking protein p130Cas regulates cell sensitivity to proteasome inhibition.The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons.Oligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survival.Processive phosphorylation: mechanism and biological importanceSRC points the way to biomarkers and chemotherapeutic targets.Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growthExpression of a phosphorylated p130(Cas) substrate domain attenuates the phosphatidylinositol 3-kinase/Akt survival pathway in tamoxifen resistant breast cancer cells.The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells.CAS directly interacts with vinculin to control mechanosensing and focal adhesion dynamics.A truncated phosphorylated p130Cas substrate domain is sufficient to drive breast cancer growth and metastasis formation in vivo.p130Cas-dependent actin remodelling regulates myogenic differentiation.Cas utilizes Nck2 to activate Cdc42 and regulate cell polarization during cell migration in response to wound healing.p130Cas substrate domain signaling promotes migration, invasion, and survival of estrogen receptor-negative breast cancer cells.Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts.Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway.Cooperative roles of Fyn and cortactin in cell migration of metastatic murine melanoma.Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association.Collagen IV regulates Caco-2 cell spreading and p130Cas phosphorylation by FAK-dependent and FAK-independent pathways.v-Crk regulates membrane dynamics and Rac activation.Coordinate suppression of Sdpr and Fhl1 expression in tumors of the breast, kidney, and prostate.EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation.p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration.Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration.
P2860
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P2860
Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate
description
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im Juli 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/07/26)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/07/26)
@nl
наукова стаття, опублікована в липні 2002
@uk
name
Differential regulation of cel ...... ns of Crk-associated substrate
@ast
Differential regulation of cel ...... ns of Crk-associated substrate
@en
Differential regulation of cel ...... ns of Crk-associated substrate
@nl
type
label
Differential regulation of cel ...... ns of Crk-associated substrate
@ast
Differential regulation of cel ...... ns of Crk-associated substrate
@en
Differential regulation of cel ...... ns of Crk-associated substrate
@nl
prefLabel
Differential regulation of cel ...... ns of Crk-associated substrate
@ast
Differential regulation of cel ...... ns of Crk-associated substrate
@en
Differential regulation of cel ...... ns of Crk-associated substrate
@nl
P2093
P2860
P3181
P356
P1476
Differential regulation of cel ...... ns of Crk-associated substrate
@en
P2093
Hiroaki Honda
Hiroko Hamasaki
Hisamaru Hirai
Jinhong Huang
Masaki Saito
Ryuichi Sakai
Tetsuya Nakamoto
Tsuyoshi Takato
P2860
P304
27265–27272
P3181
P356
10.1074/JBC.M203063200
P407
P577
2002-07-26T00:00:00Z