Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
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The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohortsThe sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavageHair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatinInsig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosisCholesterol feedback: from Schoenheimer's bottle to Scap's MELADLDual functions of Insig proteins in cholesterol homeostasisSocial exclusion changes histone modifications H3K4me3 and H3K27ac in liver tissue of wild house miceAkt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathwaysIncreased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liverInsig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienolsExercise training and calorie restriction increase SREBP-1 expression and intramuscular triglyceride in skeletal muscleDifferent cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathwaysSevere facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatinAnalysis of Schistosoma mansoni genes shared with Deuterostomia and with possible roles in host interactions.Deep RNA sequencing reveals that microRNAs play a key role in lactation in rats.Epithelial SCAP/INSIG/SREBP signaling regulates multiple biological processes during perinatal lung maturationHyperpolarized 13C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis.Genome-wide quantitative analysis of histone H3 lysine 4 trimethylation in wild house mouse liver: environmental change causes epigenetic plasticity.INSIG1 influences obesity-related hypertriglyceridemia in humans.Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle.INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.Localization of genes for V+LDL plasma cholesterol levels on two diets in the opossum Monodelphis domestica.Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductaseGene-gene and gene-environmental interactions of childhood asthma: a multifactor dimension reduction approach.Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass.Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity.Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndromeControversial association results for INSIG2 on body mass index may be explained by interactions with age and with MC4RAssociation of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent.Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes.Recent Advances in Understanding of NASH: MicroRNAs as Both Biochemical Markers and Players.Association of INSIG2 polymorphism with overweight and LDL in children.Melanocortin signaling in the CNS directly regulates circulating cholesterol.Cholesterol precursors and facial clefting.Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids.Glucose controls phosphoregulation of hydroxymethylglutaryl coenzyme A reductase through the protein phosphatase 2A-related phosphatase protein, Ppe1, and Insig in fission yeastAmino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice.Regulation of HMG-CoA reductase in mammals and yeastSterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity.
P2860
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P2860
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
description
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im September 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/09/01)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/09/01)
@nl
наукова стаття, опублікована у вересні 2005
@uk
مقالة علمية (نشرت في سبتمبر 2005)
@ar
name
Schoenheimer effect explained- ...... ice mediated by Insig proteins
@ast
Schoenheimer effect explained- ...... ice mediated by Insig proteins
@en
Schoenheimer effect explained- ...... ice mediated by Insig proteins
@nl
type
label
Schoenheimer effect explained- ...... ice mediated by Insig proteins
@ast
Schoenheimer effect explained- ...... ice mediated by Insig proteins
@en
Schoenheimer effect explained- ...... ice mediated by Insig proteins
@nl
prefLabel
Schoenheimer effect explained- ...... ice mediated by Insig proteins
@ast
Schoenheimer effect explained- ...... ice mediated by Insig proteins
@en
Schoenheimer effect explained- ...... ice mediated by Insig proteins
@nl
P2093
P2860
P921
P356
P1476
Schoenheimer effect explained- ...... ice mediated by Insig proteins
@en
P2093
Bret M. Evers
Guosheng Liang
Hiroshi Kuriyama
Jay D. Horton
Kiyosumi Takaishi
Luke J. Engelking
Michael S. Brown
Robert E. Hammer
Wei-Ping Li
P2860
P304
P356
10.1172/JCI25614
P407
P577
2005-09-01T00:00:00Z