Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
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Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class IArmand-Frappier Outstanding Student Award--The emerging role of 25-hydroxycholesterol in innate immunityUbiquitin ligases in cholesterol metabolismSequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.Human liver cytochrome P450 3A4 ubiquitination: molecular recognition by UBC7-gp78 autocrine motility factor receptor and UbcH5a-CHIP-Hsc70-Hsp40 E2-E3 ubiquitin ligase complexesRegulation of lipid metabolism: a tale of two yeasts.Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope.The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductaseThe E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR.Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated genegp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulumDifferential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells.TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesisGeranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between membranes of the ER and GolgiContribution of Accelerated Degradation to Feedback Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol Metabolism in the LiverSterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4The mammalian endoplasmic reticulum-associated degradation systemSterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cellsGenetic Variant in Flavin-Containing Monooxygenase 3 Alters Lipid Metabolism in Laying Hens in a Diet-Specific Manner.The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.Specificity and regulation of the endoplasmic reticulum-associated degradation machinery.Genetics of antipsychotic-induced weight gain: update and current perspectives.Quality control: ER-associated degradation: protein quality control and beyondRetrospective on Cholesterol Homeostasis: The Central Role of Scap.Hypoxia-inducible factor 1α activates insulin-induced gene 2 (Insig-2) transcription for degradation of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase in the liver.Membrane Protein Quantity Control at the Endoplasmic Reticulum.Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition.Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation.Unveiling the degradative route of the V247M α-sarcoglycan mutant responsible for LGMD-2D.Varicella-zoster virus glycoprotein expression differentially induces the unfolded protein response in infected cells.Hepatic cytochromes P450: structural degrons and barcodes, posttranslational modifications and cellular adapters in the ERAD-endgame.Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.Role of the ubiquitin-proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake.Proteostatic Tactics in the Strategy of Sterol Regulation.Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.UbiA prenyltransferase domain-containing protein-1 modulates HMG-CoA reductase degradation to coordinate synthesis of sterol and nonsterol isoprenoids.
P2860
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P2860
Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Sterol-induced degradation of ...... quitin ligases, gp78 and Trc8.
@ast
Sterol-induced degradation of ...... quitin ligases, gp78 and Trc8.
@en
type
label
Sterol-induced degradation of ...... quitin ligases, gp78 and Trc8.
@ast
Sterol-induced degradation of ...... quitin ligases, gp78 and Trc8.
@en
prefLabel
Sterol-induced degradation of ...... quitin ligases, gp78 and Trc8.
@ast
Sterol-induced degradation of ...... quitin ligases, gp78 and Trc8.
@en
P2093
P2860
P356
P1476
Sterol-induced degradation of ...... quitin ligases, gp78 and Trc8.
@en
P2093
Peter C W Lee
Peter V Sguigna
Russell A DeBose-Boyd
Youngah Jo
P2860
P304
20503-20508
P356
10.1073/PNAS.1112831108
P407
P577
2011-12-05T00:00:00Z