Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis - Wikidata - wikimedia - TriplyDB

Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

http://www.wikidata.org/entity/Q28509083

about

Protein prenyltransferases BLOC-1, a novel complex containing the pallidin and muted proteins involved in the biogenesis of melanosomes and platelet-dense granules The Hermansky-Pudlak syndrome 1 (HPS1) and HPS4 proteins are components of two complexes, BLOC-3 and BLOC-4, involved in the biogenesis of lysosome-related organelles BLOC-3, a protein complex containing the Hermansky-Pudlak syndrome gene products HPS1 and HPS4 BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome The gene for the muted (mu) mouse, a model for Hermansky-Pudlak syndrome, defines a novel protein which regulates vesicle trafficking Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1)Melanosomes--dark organelles enlighten endosomal membrane transport Melanocyte-specific proteins are aberrantly trafficked in melanocytes of Hermansky-Pudlak syndrome-type 3 Rab and Arf proteins in genetic diseases Regulation of osteoclasts by membrane-derived lipid mediators Molecular evolution of the Rab-escort-protein/guanine-nucleotide-dissociation-inhibitor superfamily Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9 BLOC-3 mutated in Hermansky-Pudlak syndrome is a Rab32/38 guanine nucleotide exchange factor Rab27a regulates the peripheral distribution of melanosomes in melanocytes Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells.Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2.Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4.Inherited platelet disorders: a clinical approach to diagnosis and management.Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders.Analysis of the lysosomal storage disease Chediak-Higashi syndrome.Hermansky-Pudlak syndrome and related disorders of organelle formation.Megakaryocytes and beyond: the birth of platelets.Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases.Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia.Normal and abnormal secretion by haemopoietic cells.Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway.Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.Hermansky-Pudlak syndrome: a disease of protein trafficking and organelle function.The dark side of lysosome-related organelles: specialization of the endocytic pathway for melanosome biogenesis.The secretory synapse: the secrets of a serial killer.Hermansky-Pudlak syndrome: vesicle formation from yeast to man.Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function.Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy Rab escort protein 1 (REP1) in intracellular traffic: a functional and pathophysiological overview.Mechanisms of protein delivery to melanosomes in pigment cells.The cell biology of Hermansky-Pudlak syndrome: recent advances.Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.

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P2860

Rab geranylgeranyl transferase alpha mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

http://www.wikidata.org/entity/Q28509083

description

2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

article publié dans les Procee ...... f the United States of America

@fr

artículu científicu espublizáu en 2000

@ast

im April 2000 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2000/04/11)

@sk

vědecký článek publikovaný v roce 2000

@cs

wetenschappelijk artikel (gepubliceerd op 2000/04/11)

@nl

наукова стаття, опублікована у квітні 2000

@uk

name

Rab geranylgeranyl transferase ...... ylation and platelet synthesis

@ast

Rab geranylgeranyl transferase ...... ylation and platelet synthesis

@en

Rab geranylgeranyl transferase ...... ylation and platelet synthesis

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type

label

Rab geranylgeranyl transferase ...... ylation and platelet synthesis

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Rab geranylgeranyl transferase ...... ylation and platelet synthesis

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Rab geranylgeranyl transferase ...... ylation and platelet synthesis

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prefLabel

Rab geranylgeranyl transferase ...... ylation and platelet synthesis

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Rab geranylgeranyl transferase ...... ylation and platelet synthesis

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Rab geranylgeranyl transferase ...... ylation and platelet synthesis

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Rab geranylgeranyl transferase ...... ylation and platelet synthesis

@en

P2093

E. B. McMurtrie

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E. H. Mules

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E. K. Novak

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J. C. Detter

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M. C. Seabra

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M. R. Wallace

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Q. Zhang

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R. T. Swank

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S. F. Kingsmore

http://www.w3.org/2001/XMLSchema#string

V. S. Mishra

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P2860

Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase

Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets

Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases

REP-2, a Rab escort protein encoded by the choroideremia-like gene

Protein prenyltransferases

cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys

The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: causes and consequences

Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' Collaboration

The diversity of Rab proteins in vesicle transport

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4144–4149

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scholarly article

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4437337

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P356

10.1073/PNAS.080517697

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P433

8

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97

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235616580

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10737774

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18176

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