Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
about
SIRT2 as a Therapeutic Target for Age-Related DisordersLack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stabilityHDAC6 regulates mitochondrial transport in hippocampal neuronsThe Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNSSIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesisHDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytesProteolipid protein is required for transport of sirtuin 2 into CNS myelinSeptins promote dendrite and axon development by negatively regulating microtubule stability via HDAC6-mediated deacetylation.Sirtuins in mammals: insights into their biological functionEB1, p150Glued, and Clasp1 control endothelial tubulogenesis through microtubule assembly, acetylation, and apical polarizationIncreasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations.Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling.Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation.Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development.Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytesBeyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substratesPost-translational modifications of nucleosomal histones in oligodendrocyte lineage cells in development and disease.Inhibition of Sirtuin 2 exerts neuroprotection in aging rats with increased neonatal iron intakeAn "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease.Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site.Aging-related rotenone-induced neurochemical and behavioral deficits: role of SIRT2 and redox imbalance, and neuroprotection by AK-7Knockout of silent information regulator 2 (SIRT2) preserves neurological function after experimental stroke in mice.Polarization and myelination in myelinating glia.Epigenetic memory loss in aging oligodendrocytes in the corpus callosum.The importance of NAD in multiple sclerosisLysophosphatidic acid can support the formation of membranous structures and an increase in MBP mRNA levels in differentiating oligodendrocytesMyelin sheaths are formed with proteins that originated in vertebrate lineages.Myelin proteomics: molecular anatomy of an insulating sheath.Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins.Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection.How histone deacetylases control myelination.Regulation of sirtuin function by posttranslational modificationsRole of sirtuins in stem cell differentiation.Targeting histone deacetylases: a novel approach in Parkinson's disease.Alterations in Histone Acetylases and Acetylated Histone Expression in Aging, Ethanol-Fed Rats.Juxtanodin in retinal pigment epithelial cells: expression and biological activities in regulating cell morphology and actin cytoskeleton organization.Post-Translational Tubulin Modifications in Human Astrocyte Cultures.Sirtuin 5 is Anti-apoptotic and Anti-oxidative in Cultured SH-EP Neuroblastoma Cells.The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis.The QKI-PLP pathway controls SIRT2 abundance in CNS myelin.
P2860
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P2860
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
description
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im August 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2007/02/01)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/02/01)
@nl
наукова стаття, опублікована в лютому 2007
@uk
مقالة علمية (نشرت في فبراير 2007)
@ar
name
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
@ast
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
@en
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
@nl
type
label
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
@ast
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
@en
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
@nl
prefLabel
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
@ast
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
@en
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
@nl
P2093
P921
P1476
Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
@en
P2093
Cherie M Southwood
Marcello Peppi
Sylvia Dryden
P2888
P304
P356
10.1007/S11064-006-9127-6
P577
2006-08-25T00:00:00Z
P6179
1043874656