Linking class-switch recombination with somatic hypermutation.
about
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutationAID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.Somatic hypermutation of the AID transgene in B and non-B cellsGenetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombinationExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesAID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switchingAltered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant miceMobile DNA and evolution in the 21st centuryInduction of IgG3 to LPS via Toll-like receptor 4 co-stimulation.Different Somatic Hypermutation Levels among Antibody Subclasses Disclosed by a New Next-Generation Sequencing-Based Antibody Repertoire Analysis.A novel modular antigen delivery system for immuno targeting of human 6-sulfo LacNAc-positive blood dendritic cells (SlanDCs)A human nuclease specific for G4 DNAA hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs.Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombinationThe transcriptional programme of antibody class switching involves the repressor Bach2.Primary immunodeficiency diseases: natural mutant models for the study of the immune system.AID and mismatch repair in antibody diversification.De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Class-switch recombination: after the dawn of AID.The hyper IgM syndrome--an evolving story.Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects.DNA deamination in immunity.Immunoglobulin replacement therapy in primary antibody deficiency diseases--maximizing success.Why repetitive DNA is essential to genome function.Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties.Quantitative regulation of class switch recombination by switch region transcription.The function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutationThe C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells.Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast.Surface profiles for subclassification of chronic lymphocytic leukemia.Current concepts of IgE regulation and impact of genetic determinants.Gonadal steroids and humoral immunity.Somatic structural variation and cancer.Presence of somatic hypermutation and activation-induced cytidine deaminase in acute lymphoblastic leukemia L2 with t(14;18)(q32;q21).Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL.Expression of activation-induced cytidine deaminase is associated with a poor prognosis of diffuse large B cell lymphoma patients treated with CHOP-based chemotherapy.AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.
P2860
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P2860
Linking class-switch recombination with somatic hypermutation.
description
2001 nî lūn-bûn
@nan
2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Linking class-switch recombination with somatic hypermutation.
@ast
Linking class-switch recombination with somatic hypermutation.
@en
Linking class-switch recombination with somatic hypermutation.
@nl
type
label
Linking class-switch recombination with somatic hypermutation.
@ast
Linking class-switch recombination with somatic hypermutation.
@en
Linking class-switch recombination with somatic hypermutation.
@nl
prefLabel
Linking class-switch recombination with somatic hypermutation.
@ast
Linking class-switch recombination with somatic hypermutation.
@en
Linking class-switch recombination with somatic hypermutation.
@nl
P2860
P356
P1476
Linking class-switch recombination with somatic hypermutation.
@en
P2093
P2860
P2888
P304
P356
10.1038/35080033
P577
2001-07-01T00:00:00Z
P6179
1021224791