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Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

http://www.wikidata.org/entity/Q28512961

about

Sphingolipids: a potential molecular approach to treat allergic inflammation The role of sphingosine-1-phosphate transporter Spns2 in immune system function FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors The emerging role of FTY720 (Fingolimod) in cancer treatment Sphingosine-1-phosphate in chronic intestinal inflammation and cancer A review of ceramide analogs as potential anticancer agents Moesin controls clathrin-mediated S1PR1 internalization in T cells Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ.Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3 Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration.Sphingosine 1-phosphate chemical biology A rapid assay for assessment of sphingosine kinase inhibitors and substrates Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors Regulation of learning and memory by meningeal immunity: a key role for IL-4 Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs.Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist.Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury.Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists.Biological roles of lysophospholipid receptors revealed by genetic null mice: an update.S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species.4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.Down-regulation of S1P1 receptor surface expression by protein kinase C inhibition.Fingolimod attenuates splenocyte-induced demyelination in cerebellar slice cultures.Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2 Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient.Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis.Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation.Advances in the management of peritoneal mesothelioma "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.Fingolimod for relapsing multiple sclerosis: an update.FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3.Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system.Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 - Jekyll Hidden behind Hyde Roles of Sphingolipid Metabolism in Pancreatic β Cell Dysfunction Induced by Lipotoxicity.Insights into the pharmacological relevance of lysophospholipid receptors.

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Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

http://www.wikidata.org/entity/Q28512961

description

2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

article publié dans la revue scientifique Journal of Biological Chemistry

@fr

artículu científicu espublizáu en 2005

@ast

im November 2005 veröffentlichter wissenschaftlicher Artikel

@de

scientific journal article

@en

vedecký článok (publikovaný 2005/11/04)

@sk

vědecký článek publikovaný v roce 2005

@cs

wetenschappelijk artikel (gepubliceerd op 2005/11/04)

@nl

наукова стаття, опублікована в листопаді 2005

@uk

name

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

@ast

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

@en

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

@nl

type

label

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

@ast

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

@en

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

@nl

prefLabel

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

@ast

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

@en

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

@nl

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Journal of Biological Chemistry

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Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

@en

P2093

Ashley H Snyder

http://www.w3.org/2001/XMLSchema#string

Kenneth S K Tung

http://www.w3.org/2001/XMLSchema#string

Kevin R Lynch

http://www.w3.org/2001/XMLSchema#string

Klaus Ley

http://www.w3.org/2001/XMLSchema#string

Margaret A Morris

http://www.w3.org/2001/XMLSchema#string

Molly A Zigler

http://www.w3.org/2001/XMLSchema#string

Ran Zhu

http://www.w3.org/2001/XMLSchema#string

Sangderk Lee

http://www.w3.org/2001/XMLSchema#string

Sonia Pearson-White

http://www.w3.org/2001/XMLSchema#string

Stacey L Sheasley-O'neill

http://www.w3.org/2001/XMLSchema#string

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36865-36872

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scholarly article

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10.1074/JBC.M506293200

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44

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280

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Victor H Engelhard

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2005-08-10T00:00:00Z

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16093248

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