FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells
about
Ceramide synthases at the centre of sphingolipid metabolism and biologyRole of Sphingolipids in the Pathobiology of Lung InflammationS1P control of endothelial integrityDistinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells.Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosisDown-regulation of S1P1 receptor surface expression by protein kinase C inhibition.Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cellsCeramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.Ceramides predict verbal memory performance in coronary artery disease patients undertaking exercise: a prospective cohort pilot studyDevelopment of small-molecule inhibitors of sphingosine-1-phosphate signaling(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activitySphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteinsIdentification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma.Sphingolipids: regulators of crosstalk between apoptosis and autophagyA fluorescent assay for ceramide synthase activity.Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration.Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration.Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury.Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders.Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials.Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology.Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells.Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients.FTY720 enhances chemosensitivity of colon cancer cells to doxorubicin and etoposide via the modulation of P-glycoprotein and multidrug resistance protein 1.Inhibition of sphingosine 1-phosphate signaling ameliorates murine nonalcoholic steatohepatitis.Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2.Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720.Abnormal gangliosides are localized in lipid rafts in Sanfilippo (MPS3a) mouse brain.Activation of sphingosine 1-phosphate receptor-1 by SEW2871 improves cognitive function in Alzheimer's disease model ratsCeramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase.FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.Use of a biomarker in exposure-response analysis to support dose selection for fingolimod.
P2860
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P2860
FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
FTY720 inhibits ceramide synth ...... n human lung endothelial cells
@ast
FTY720 inhibits ceramide synth ...... n human lung endothelial cells
@en
FTY720 inhibits ceramide synth ...... n human lung endothelial cells
@nl
type
label
FTY720 inhibits ceramide synth ...... n human lung endothelial cells
@ast
FTY720 inhibits ceramide synth ...... n human lung endothelial cells
@en
FTY720 inhibits ceramide synth ...... n human lung endothelial cells
@nl
prefLabel
FTY720 inhibits ceramide synth ...... n human lung endothelial cells
@ast
FTY720 inhibits ceramide synth ...... n human lung endothelial cells
@en
FTY720 inhibits ceramide synth ...... n human lung endothelial cells
@nl
P2093
P2860
P356
P1476
FTY720 inhibits ceramide synth ...... n human lung endothelial cells
@en
P2093
Anastasia Skobeleva
Evgeny V Berdyshev
Irina Gorshkova
Joe G N Garcia
Robert Bittman
Steven M Dudek
Tamara Mirzapoiazova
Viswanathan Natarajan
Xuequan Lu
P2860
P304
P356
10.1074/JBC.M805186200
P407
P577
2009-02-27T00:00:00Z