Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. - Wikidata - wikimedia - TriplyDB

Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.

Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.

http://www.wikidata.org/entity/Q34974825

about

Ceramide synthases at the centre of sphingolipid metabolism and biology Mammalian ceramide synthases Fingolimod for the treatment of neurological diseases-state of play and future perspectives Defect of insulin signal in peripheral tissues: Important role of ceramide The cell biology of fat expansion Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells Modulation of ceramide synthase activity via dimerization.Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers Differential regulation of autophagy and cell viability by ceramide species.(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins Sphingolipids: regulators of crosstalk between apoptosis and autophagy A fluorescent assay for ceramide synthase activity.Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi.Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration.Sphingolipid profile alters in retinal dystrophic P23H-1 rats and systemic FTY720 can delay retinal degeneration.Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury.Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders.Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N-acyl chain.Targeting sphingolipid metabolism in head and neck cancer: rational therapeutic potentials.Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.Regulation of metabolism and transport of sphingosine-1-phosphate in mammalian cells.Sphingosine 1-phosphate signalling in cancer.Oncogenic properties of sphingosine kinases in haematological malignancies.Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology.The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod.Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase.Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation.Modulation of IL-33/ST2-TIR and TLR signalling pathway by fingolimod and analogues in immune cells.Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients.FTY720 enhances chemosensitivity of colon cancer cells to doxorubicin and etoposide via the modulation of P-glycoprotein and multidrug resistance protein 1.FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease.Gilenya (FTY720) inhibits acid sphingomyelinase by a mechanism similar to tricyclic antidepressants.

P2860

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P2860

Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner.

http://www.wikidata.org/entity/Q34974825

description

2009 nî lūn-bûn

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2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2009 թվականի ապրիլին հրատարակված գիտական հոդված

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年學術文章

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Ceramide synthesis is modulate ...... chain length-dependent manner.

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P1433

Journal of Biological Chemistry

P1476

Ceramide synthesis is modulate ...... chain length-dependent manner.

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P2093

Elad L Laviad

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Hyejung Park

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Robert Bittman

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Sujoy Lahiri

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Xuequan Lu

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P2860

Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells

LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity

The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2

Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells

LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor

Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

P304

16090-16098

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scholarly article

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10.1074/JBC.M807438200

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24

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284

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Anthony H. Futerman

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2009-04-08T00:00:00Z

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19357080

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2713526

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