Cancer evolution is associated with pervasive positive selection on globally expressed genes
about
Oncogenomic portals for the visualization and analysis of genome-wide cancer dataPeto's paradox and the hallmarks of cancer: constructing an evolutionary framework for understanding the incidence of cancerThe landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selectionDeleterious Passengers in Adapting PopulationsRole of the neural niche in brain metastatic cancer.Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor.Re-emergent human adenovirus genome type 7d caused an acute respiratory disease outbreak in Southern China after a twenty-one year absence.The reverse evolution from multicellularity to unicellularity during carcinogenesis.Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect.Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.Recurrent somatic mutations in regulatory regions of human cancer genomesExtremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.Bringing Down Cancer Aircraft: Searching for Essential Hypomutated Proteins in Skin MelanomaCancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii.Negative selection maintains transcription factor binding motifs in human cancer.Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer TypesPrevalent Accumulation of Non-Optimal Codons through Somatic Mutations in Human Cancers.Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor EvolutionThe landscape of sex-differential transcriptome and its consequent selection in human adultsMutational Signatures Are Critical for Proper Estimation of Purifying Selection Pressures in Cancer Somatic Mutation Data When Using the dN/dS Metric.Early and multiple origins of metastatic lineages within primary tumorsThe TissueNet v.2 database: A quantitative view of protein-protein interactions across human tissues.Challenges in the management of advanced, ER-positive, HER2-negative breast cancer.Variation in KRAS driver substitution distributions between tumor types is determined by both mutation and natural selection.Between-region genetic divergence reflects the mode and tempo of tumor evolution.Progression inference for somatic mutations in cancer.New paradigms in clonal evolution: punctuated equilibrium in cancer.Measuring cancer evolution from the genome.Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types.Mutation-profile-based methods for understanding selection forces in cancer somatic mutations: a comparative analysis.The Somatic Nature of Cancer Allows It to Affect Highly Constrained Genes.Rapid Genetic Adaptation during the First Four Months of Survival under Resource Exhaustion.Signatures of positive selection reveal a universal role of chromatin modifiers as cancer driver genes.Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect.The dJ/dS Ratio Test Reveals Hundreds of Novel Putative Cancer Drivers.Universal Patterns of Selection in Cancer and Somatic Tissues.The DifferentialNet database of differential protein-protein interactions in human tissues.Identification of metastasis driver genes by massive parallel sequencing of successive steps of breast cancer progression.Modeling the Subclonal Evolution of Cancer Cell Populations.
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P2860
Cancer evolution is associated with pervasive positive selection on globally expressed genes
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Cancer evolution is associated ...... on on globally expressed genes
@ast
Cancer evolution is associated ...... on on globally expressed genes
@en
Cancer evolution is associated ...... on on globally expressed genes
@nl
type
label
Cancer evolution is associated ...... on on globally expressed genes
@ast
Cancer evolution is associated ...... on on globally expressed genes
@en
Cancer evolution is associated ...... on on globally expressed genes
@nl
prefLabel
Cancer evolution is associated ...... on on globally expressed genes
@ast
Cancer evolution is associated ...... on on globally expressed genes
@en
Cancer evolution is associated ...... on on globally expressed genes
@nl
P2093
P2860
P3181
P1433
P1476
Cancer evolution is associated ...... on on globally expressed genes
@en
P2093
Ruth Barshir
Ruth Hershberg
Sheli L Ostrow
P2860
P304
P3181
P356
10.1371/JOURNAL.PGEN.1004239
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P577
2014-03-06T00:00:00Z