Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis
about
The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasisThe rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferencesPotent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acidsCyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenoloneCPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase geneBile acids: regulation of synthesisJTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs.Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasisMutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosiscyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostateActivation of the orphan nuclear receptor steroidogenic factor 1 by oxysterolsMaternal protein restriction elevates cholesterol in adult rat offspring due to repressive changes in histone modifications at the cholesterol 7alpha-hydroxylase promoterRapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebratesCombined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis.Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating ratsUrinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challengeThe correlation between the expression of genes involved in drug metabolism and the blood level of tacrolimus in liver transplant receiptsCholesterol kinetics in subjects with bile fistula. Positive relationship between size of the bile acid precursor pool and bile acid synthetic rate.Regulation of hepatic 7 alpha-hydroxylase expression by dietary psyllium in the hamster.Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences.Resistance to dietary-induced hypercholesterolemia exhibited by a unique strain of New Zealand white rabbits.The liver plays a key role in whole body sterol accretion of the neonatal Golden Syrian hamster.A pleiotropic role for the orphan nuclear receptor small heterodimer partner in lipid homeostasis and metabolic pathways.The hepatic transcriptome of young suckling and aging intrauterine growth restricted male ratsAnalysis of bioactive oxysterols in newborn mouse brain by LC/MS.Activation of the silent endogenous cholesterol-7-alpha-hydroxylase gene in rat hepatoma cells: a new complementation group having resistance to 25-hydroxycholesterol.Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression.Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamsterOST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids.Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys.Hepatic bile acid metabolism in the neonatal hamster: expansion of the bile acid pool parallels increased Cyp7a1 expression levelsInability to fully suppress sterol synthesis rates with exogenous sterol in embryonic and extraembyronic fetal tissuesComplex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism.Synergism between nuclear receptors bound to specific hormone response elements of the hepatic control region-1 and the proximal apolipoprotein C-II promoter mediate apolipoprotein C-II gene regulation by bile acids and retinoids.Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner.Insulin-dependent suppression of cholesterol 7α-hydroxylase is a possible link between glucose and cholesterol metabolisms.Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain?Unexpected inhibition of cholesterol 7 alpha-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits.
P2860
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P2860
Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis
description
1990 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1990
@ast
im Mai 1990 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1990/05/15)
@sk
vědecký článek publikovaný v roce 1990
@cs
wetenschappelijk artikel (gepubliceerd op 1990/05/15)
@nl
наукова стаття, опублікована в травні 1990
@uk
name
Cloning and regulation of chol ...... zyme in bile acid biosynthesis
@ast
Cloning and regulation of chol ...... zyme in bile acid biosynthesis
@en
Cloning and regulation of chol ...... zyme in bile acid biosynthesis
@nl
type
label
Cloning and regulation of chol ...... zyme in bile acid biosynthesis
@ast
Cloning and regulation of chol ...... zyme in bile acid biosynthesis
@en
Cloning and regulation of chol ...... zyme in bile acid biosynthesis
@nl
prefLabel
Cloning and regulation of chol ...... zyme in bile acid biosynthesis
@ast
Cloning and regulation of chol ...... zyme in bile acid biosynthesis
@en
Cloning and regulation of chol ...... zyme in bile acid biosynthesis
@nl
P2093
P2860
P1476
Cloning and regulation of chol ...... zyme in bile acid biosynthesis
@en
P2093
C. A. Slaughter
D. F. Jelinek
D. W. Russell
S. Andersson
P2860
P304
P407
P577
1990-05-15T00:00:00Z