Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
about
The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferationBile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expressionBile acid transportersBile acids: regulation of apoptosis by ursodeoxycholic acidBile acids: regulation of synthesisBile acids are nutrient signaling hormonesPhospholipid--driven gene regulationBridging cell surface receptor with nuclear receptors in control of bile acid homeostasisSmall Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)MAFG is a transcriptional repressor of bile acid synthesis and metabolismThe nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesisRole of nuclear receptor SHP in metabolism and cancer.Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in miceRegulation of bile acid synthesis by fat-soluble vitamins A and D.Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetesalpha(1)-fetoprotein transcription factor (FTF)/liver receptor homolog-1 (LRH-1) is an essential lipogenic regulatorClinical application of transcriptional activators of bile salt transporters.Discovering networks of perturbed biological processes in hepatocyte culturesA putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine.AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acidsDeciphering the nuclear bile acid receptor FXR paradigm.The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder fillingHepatocyte nuclear factor (HNF) 4α transactivation of cytochrome P450 (Cyp) 2d40 promoter is enhanced during pregnancy in mice.Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programsA nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.Farnesoid X receptor represses hepatic human APOA gene expression.LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitisImpaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia.Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunityLRH-1-dependent glucose sensing determines intermediary metabolism in liver.Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism.Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo.A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver.Emerging actions of the nuclear receptor LRH-1 in the gut.The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation.LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.Bile acids: chemistry, physiology, and pathophysiology.
P2860
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P2860
Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Liver receptor homolog-1 regul ...... lation of bile acid synthesis.
@ast
Liver receptor homolog-1 regul ...... lation of bile acid synthesis.
@en
type
label
Liver receptor homolog-1 regul ...... lation of bile acid synthesis.
@ast
Liver receptor homolog-1 regul ...... lation of bile acid synthesis.
@en
prefLabel
Liver receptor homolog-1 regul ...... lation of bile acid synthesis.
@ast
Liver receptor homolog-1 regul ...... lation of bile acid synthesis.
@en
P2093
P2860
P356
P1476
Liver receptor homolog-1 regul ...... ulation of bile acid synthesis
@en
P2093
Bryan Goodwin
Daniel R Schmidt
Mihwa Choi
Robert E Hammer
Steven A Kliewer
Youn-Kyoung Lee
Yuan Zhang
P2860
P304
P356
10.1210/ME.2007-0565
P577
2008-03-06T00:00:00Z