Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. - Wikidata - wikimedia - TriplyDB

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

http://www.wikidata.org/entity/Q36693487

about

The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression Bile acid transporters Bile acids: regulation of apoptosis by ursodeoxycholic acid Bile acids: regulation of synthesis Bile acids are nutrient signaling hormones Phospholipid--driven gene regulation Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)MAFG is a transcriptional repressor of bile acid synthesis and metabolism The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis Role of nuclear receptor SHP in metabolism and cancer.Nuclear receptor LRH-1 induces the reproductive neuropeptide kisspeptin in the hypothalamus.Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice Regulation of bile acid synthesis by fat-soluble vitamins A and D.Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes alpha(1)-fetoprotein transcription factor (FTF)/liver receptor homolog-1 (LRH-1) is an essential lipogenic regulator Clinical application of transcriptional activators of bile salt transporters.Discovering networks of perturbed biological processes in hepatocyte cultures A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine.AKR1B7 is induced by the farnesoid X receptor and metabolizes bile acids Deciphering the nuclear bile acid receptor FXR paradigm.The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling Hepatocyte nuclear factor (HNF) 4α transactivation of cytochrome P450 (Cyp) 2d40 promoter is enhanced during pregnancy in mice.Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects.Farnesoid X receptor represses hepatic human APOA gene expression.LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function.Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia.Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity LRH-1-dependent glucose sensing determines intermediary metabolism in liver.Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism.Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo.A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver.Emerging actions of the nuclear receptor LRH-1 in the gut.The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation.LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.Bile acids: chemistry, physiology, and pathophysiology.

P2860

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P2860

Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.

http://www.wikidata.org/entity/Q36693487

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Liver receptor homolog-1 regul ...... lation of bile acid synthesis.

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Liver receptor homolog-1 regul ...... lation of bile acid synthesis.

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type

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Liver receptor homolog-1 regul ...... lation of bile acid synthesis.

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Liver receptor homolog-1 regul ...... lation of bile acid synthesis.

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prefLabel

Liver receptor homolog-1 regul ...... lation of bile acid synthesis.

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Liver receptor homolog-1 regul ...... lation of bile acid synthesis.

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P1433

Molecular Endocrinology

P1476

Liver receptor homolog-1 regul ...... ulation of bile acid synthesis

@en

P2093

Bryan Goodwin

http://www.w3.org/2001/XMLSchema#string

Daniel R Schmidt

http://www.w3.org/2001/XMLSchema#string

Li Peng

http://www.w3.org/2001/XMLSchema#string

Mihwa Choi

http://www.w3.org/2001/XMLSchema#string

Robert E Hammer

http://www.w3.org/2001/XMLSchema#string

Steven A Kliewer

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Youn-Kyoung Lee

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Yuan Zhang

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P2860

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene

Quantitative real-time PCR protocol for analysis of nuclear receptor signaling pathways.

The enzymes, regulation, and genetics of bile acid synthesis

Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine

The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

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1345-1356

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scholarly article

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10.1210/ME.2007-0565

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6

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22

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Carolyn L. Cummins

David J Mangelsdorf

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2008-03-06T00:00:00Z

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5529823

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18323469

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2409274

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