Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity
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Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptorsReceptors for PTH and PTHrP: their biological importance and functional propertiesThe repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis.The PTH/PTHrP receptor in Jansen's metaphyseal chondrodysplasia.G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes.Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH.Renal phosphate wasting in the absence of adenylyl cyclase 6Disease-causing mutation in PKR2 receptor reveals a critical role of positive charges in the second intracellular loop for G-protein coupling and receptor trafficking.'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformationsDifferential determinants for coupling of distinct G proteins with the class B secretin receptor.Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice.Eliminating phosphorylation sites of the parathyroid hormone receptor type 1 differentially affects stimulation of phospholipase C and receptor internalization.From parathyroid hormone to cytosolic Ca2+ signals.The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression.Parathyroid hormone (1-34) modulates odontoblast proliferation and apoptosis via PKA and PKC-dependent pathways.Heterotrimeric G proteins in the control of parathyroid hormone actions.Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with beta-arrestin2 for ERK1/2 activation.Parathyroid hormone receptor internalization is independent of protein kinase A and phospholipase C activation.Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C.Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase.Signaling and phosphorylation-impaired mutants of the rat follitropin receptor reveal an activation- and phosphorylation-independent but arrestin-dependent pathway for internalization.Identification of an essential amino acid motif within the C terminus of the pituitary adenylate cyclase-activating polypeptide type I receptor that is critical for signal transduction but not for receptor internalization.Characterization of a PTH1R missense mutation responsible for Jansen type metaphyseal chondrodysplasia.Two cytoplasmic loops of the glucagon receptor are required to elevate cAMP or intracellular calcium.RNA editing of the human serotonin 5-HT2C receptor alters receptor-mediated activation of G13 protein.Identification of cytoplasmic domains of hVPAC1 receptor required for activation of adenylyl cyclase. Crucial role of two charged amino acids strictly conserved in class II G protein-coupled receptors.A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1.Zebrafish express the common parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) and a novel receptor (PTH3R) that is preferentially activated by mammalian and fugufish parathyroid hormone-related peptide.Induced Gnas(R201H) expression from the endogenous Gnas locus causes fibrous dysplasia by up-regulating Wnt/β-catenin signaling.
P2860
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P2860
Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity
description
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1997
@ast
im März 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/03/14)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/03/14)
@nl
наукова стаття, опублікована в березні 1997
@uk
name
Mutations in the second cytopl ...... lated phospholipase C activity
@ast
Mutations in the second cytopl ...... lated phospholipase C activity
@en
Mutations in the second cytopl ...... lated phospholipase C activity
@nl
type
label
Mutations in the second cytopl ...... lated phospholipase C activity
@ast
Mutations in the second cytopl ...... lated phospholipase C activity
@en
Mutations in the second cytopl ...... lated phospholipase C activity
@nl
prefLabel
Mutations in the second cytopl ...... lated phospholipase C activity
@ast
Mutations in the second cytopl ...... lated phospholipase C activity
@en
Mutations in the second cytopl ...... lated phospholipase C activity
@nl
P2093
P2860
P356
P1476
Mutations in the second cytopl ...... lated phospholipase C activity
@en
P2093
A. Abou-Samra
A. Iida-Klein
F. R. Bringhurst
G. V. Segre
J. T. Potts
M. T. Drake
M. Takemura
P2860
P304
P356
10.1074/JBC.272.11.6882
P407
P577
1997-03-14T00:00:00Z