Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations
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Structural basis for parathyroid hormone-related protein binding to the parathyroid hormone receptor and design of conformation-selective peptidesPTH receptor-1 signalling-mechanistic insights and therapeutic prospectsStructural Basis for Antibody Discrimination between Two Hormones That Recognize the Parathyroid Hormone ReceptorPTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids.Sustained cyclic AMP production by parathyroid hormone receptor endocytosis.Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogsActions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor.International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors--family B G protein-coupled receptors.Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probeTheme and variations on kinetics of GPCR activation/deactivation.Non-canonical signaling of the PTH receptorAltered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor.Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling.Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm.Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTHEliminating phosphorylation sites of the parathyroid hormone receptor type 1 differentially affects stimulation of phospholipase C and receptor internalization.Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation.Allosteric modulators of class B G-protein-coupled receptorsMechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells.PTH and PTHrP signaling in osteoblastsSix Weeks of Daily Abaloparatide Treatment Increased Vertebral and Femoral Bone Mineral Density, Microarchitecture and Strength in Ovariectomized Osteopenic RatsIdentification of an orally active small-molecule PTHR1 agonist for the treatment of hypoparathyroidism.Parathyroid Hormone-Related Protein, Its Regulation of Cartilage and Bone Development, and Role in Treating Bone Diseases.Role of amino acid side chains in region 17-31 of parathyroid hormone (PTH) in binding to the PTH receptor.Residue 17 of sauvagine cross-links to the first transmembrane domain of corticotropin-releasing factor receptor 1 (CRFR1).Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys.Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues.Chemistry as an expanding resource in protein science: fully synthetic and fully active human parathyroid hormone-related protein (1-141).Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse AgonistDevelopment of Potent, Protease-Resistant Agonists of the Parathyroid Hormone Receptor with Broad β Residue Distribution.G protein-coupled receptor modulation with pepducins: moving closer to the clinic
P2860
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P2860
Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Mechanisms of ligand binding t ...... coupled receptor conformations
@ast
Mechanisms of ligand binding t ...... coupled receptor conformations
@en
type
label
Mechanisms of ligand binding t ...... coupled receptor conformations
@ast
Mechanisms of ligand binding t ...... coupled receptor conformations
@en
prefLabel
Mechanisms of ligand binding t ...... coupled receptor conformations
@ast
Mechanisms of ligand binding t ...... coupled receptor conformations
@en
P2093
P2860
P356
P1476
Mechanisms of ligand binding t ...... coupled receptor conformations
@en
P2093
Harald Jüppner
John T Potts
Matthew J Mahon
Murat Bastepe
Thomas Dean
Thomas J Gardella
P2860
P304
P356
10.1210/ME.2005-0349
P577
2005-12-08T00:00:00Z