Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain
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JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extensionJSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathwayCIKS, a connection to Ikappa B kinase and stress-activated protein kinaseRegulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinaseNIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domainMEK kinases are regulated by EGF and selectively interact with Rac/Cdc42Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activationA RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathwayMEKK1 binds raf-1 and the ERK2 cascade componentsContribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth controlAxin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activationMEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinasesGrb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factorIdentification of two essential phosphorylated threonine residues in the catalytic domain of Mekk1. Indirect activation by Pak3 and protein kinase CCloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathwayMAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cellsWNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain IIA novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1GRASP-1 is a neuronal scaffold protein for the JNK signaling pathwayp115 Rho GTPase activating protein interacts with MEKK1.MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells.Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domainActivation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylationThe isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase.The c-jun kinase/stress-activated pathway: regulation, function and role in human disease.Signaling by the germinal center kinase family of protein kinases.Deltex regulates T-cell activation by targeted degradation of active MEKK1.Novel roles of specific isoforms of protein kinase C in activation of the c-fos serum response elementFunctional role for protein kinase Cbeta as a regulator of stress-activated protein kinase activation and monocytic differentiation of myeloid leukemia cells.Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage.MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis.Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases.Poxviral regulation of the host NF-kappaB response: the vaccinia virus M2L protein inhibits induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells.Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1p38 and p42/44 MAPKs differentially regulate progesterone receptor A and B isoform stabilization.RNF135, RING finger protein, promotes the proliferation of human glioblastoma cells in vivo and in vitro via the ERK pathway.
P2860
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P2860
Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain
description
1996 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1996
@ast
im Mai 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/05/28)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/05/28)
@nl
наукова стаття, опублікована в травні 1996
@uk
name
Cloning of rat MEK kinase 1 cD ...... with a large regulatory domain
@ast
Cloning of rat MEK kinase 1 cD ...... with a large regulatory domain
@en
Cloning of rat MEK kinase 1 cD ...... with a large regulatory domain
@nl
type
label
Cloning of rat MEK kinase 1 cD ...... with a large regulatory domain
@ast
Cloning of rat MEK kinase 1 cD ...... with a large regulatory domain
@en
Cloning of rat MEK kinase 1 cD ...... with a large regulatory domain
@nl
prefLabel
Cloning of rat MEK kinase 1 cD ...... with a large regulatory domain
@ast
Cloning of rat MEK kinase 1 cD ...... with a large regulatory domain
@en
Cloning of rat MEK kinase 1 cD ...... with a large regulatory domain
@nl
P2093
P2860
P356
P1476
Cloning of rat MEK kinase 1 cD ...... with a large regulatory domain
@en
P2093
C A Vanderbilt
D J Robbins
J M English
L B Christerson
P2860
P304
P356
10.1073/PNAS.93.11.5291
P407
P577
1996-05-01T00:00:00Z