Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans
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Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cellsThe kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinaseEukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivoEvidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulinInterleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cellsThe PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3Small G proteins in islet beta-cell function.Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial.Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.Short-term regulation of insulin gene transcription by glucose.Interleukin-1 beta targeted therapy for type 2 diabetes.Ceramide formation as a target in beta-cell survival and function.Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass.Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction.The role of glycogen synthase kinase 3-β in immunity and cell cycle: implications in esophageal cancer.The role of mTORC1 in regulating protein synthesis and skeletal muscle mass in response to various mechanical stimuli.A novel mechanism for the control of translation initiation by amino acids, mediated by phosphorylation of eukaryotic initiation factor 2B.Glucose-stimulated protein synthesis in pancreatic beta-cells parallels an increase in the availability of the translational ternary complex (eIF2-GTP.Met-tRNAi) and the dephosphorylation of eIF2 alpha.Initiation factor eIF2B not p70 S6 kinase is involved in the activation of the PI-3K signalling pathway induced by the v-src oncogene.Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells.The acid sphingomyelinase inhibitor SR33557 counteracts TNF-alpha-mediated potentiation of IL-1beta-induced NF-kappaB activation in the insulin-producing cell line Rinm5F.Insulin mediates glucose-stimulated phosphorylation of PHAS-I by pancreatic beta cells. An insulin-receptor mechanism for autoregulation of protein synthesis by translation.Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets.Molecular mechanisms for the control of translation by insulin.A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation.Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.Initiation factor 2B activity is regulated by protein phosphatase 1, which is activated by the mitogen-activated protein kinase-dependent pathway in insulin-like growth factor 1-stimulated neuronal cells.MKK3 signalling plays an essential role in leukocyte-mediated pancreatic injury in the multiple low-dose streptozotocin model.Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.
P2860
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P2860
Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans
description
1996 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հունվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1996
@ast
im Januar 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/01/26)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/01/26)
@nl
наукова стаття, опублікована в січні 1996
@uk
name
Glucose stimulates the activit ...... lated rat islets of Langerhans
@ast
Glucose stimulates the activit ...... lated rat islets of Langerhans
@en
Glucose stimulates the activit ...... lated rat islets of Langerhans
@nl
type
label
Glucose stimulates the activit ...... lated rat islets of Langerhans
@ast
Glucose stimulates the activit ...... lated rat islets of Langerhans
@en
Glucose stimulates the activit ...... lated rat islets of Langerhans
@nl
prefLabel
Glucose stimulates the activit ...... lated rat islets of Langerhans
@ast
Glucose stimulates the activit ...... lated rat islets of Langerhans
@en
Glucose stimulates the activit ...... lated rat islets of Langerhans
@nl
P2093
P2860
P356
P1476
Glucose stimulates the activit ...... lated rat islets of Langerhans
@en
P2093
P2860
P304
P356
10.1074/JBC.271.4.2121
P407
P577
1996-01-01T00:00:00Z