Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
about
High glucose suppresses human islet insulin biosynthesis by inducing miR-133a leading to decreased polypyrimidine tract binding protein-expressionMechanisms of action of glucagon-like peptide 1 in the pancreasINS-gene mutations: from genetics and beta cell biology to clinical diseaseTranslational control mechanisms in metabolic regulation: critical role of RNA binding proteins, microRNAs, and cytoplasmic RNA granulesControl of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasisControl of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequenceRegulation of the insulin gene by glucose and fatty acidsRNA-binding proteins implicated in the hypoxic response.Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis.Minireview: posttranscriptional regulation of the insulin and insulin-like growth factor systemsmiR-196b-mediated translation regulation of mouse insulin2 via the 5'UTRGene expression profiling in single cells from the pancreatic islets of Langerhans reveals lognormal distribution of mRNA levels.Insulin granules. Insulin secretory granules control autophagy in pancreatic β cells.Glutamine stimulates biosynthesis and secretion of insulin-like growth factor 2 (IGF2), an autocrine regulator of beta cell mass and function.Molecular insights into insulin action and secretion.RanBP2/Nup358 potentiates the translation of a subset of mRNAs encoding secretory proteins.Glucose-stimulated translation regulation of insulin by the 5' UTR-binding proteins.Identification of glucose-regulated miRNAs from pancreatic {beta} cells reveals a role for miR-30d in insulin transcriptionGlucotoxicity and beta-cell failure in type 2 diabetes mellitus.Post-Transcriptional Control of the Hypoxic Response by RNA-Binding Proteins and MicroRNAs.Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress.Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.RNA-binding protein HuD controls insulin translationPolymorphism of the insulin gene is associated with increased prostate cancer risk.miR-25 and miR-92a regulate insulin I biosynthesis in rats.PTB and TIAR binding to insulin mRNA 3'- and 5'UTRs; implications for insulin biosynthesis and messenger stability.Regulation of β-cell function by RNA-binding proteins.The selective recruitment of mRNA to the ER and an increase in initiation are important for glucose-stimulated proinsulin synthesis in pancreatic beta-cells.The dynamic plasticity of insulin production in β-cells.Novel splice variant of mouse insulin2 mRNA: implications for insulin expression.Insulin secretory deficiency and glucose intolerance in Rab3A null mice.Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.Polymorphism in IGF-2 as a surrogate marker for predisposition towards tobacco chewing-mediated oral cancer.Glucose Controls the Expression of Polypyrimidine Tract-Binding Protein 1 via the Insulin Receptor Signaling Pathway in Pancreatic β Cells
P2860
Q21136357-D35A2D62-DD08-4DB5-A0AD-FF9D5AB50E42Q24683764-29869649-F49F-4520-B20C-C173F56D1D55Q27013618-353C73A9-FAA1-4432-B161-5579744AA373Q27022700-1F4F389B-D28D-4B03-82F1-1F41C624038BQ28258427-1970C00D-CFCD-4645-BE5A-7639F3C1CA5FQ28583369-EFF69F36-B558-4777-A794-DA655F6EB132Q28609723-3073F471-A13A-4276-98C0-B754FCDFFD6AQ33703426-D18FB8EE-B13C-4D45-90B9-5DD29B3E030AQ33733949-1D09CF3A-CD56-4132-A6E5-143BFBEAFBBEQ33772376-FC1A817C-E59A-4DEB-AE7E-BF2AEC9054D6Q33863937-C6F0DA39-80EA-4D32-BBF0-EB0A30090E53Q34056088-B64165E2-34AE-4B67-A33D-16ED84D400DBQ34463845-DF60143B-0C3A-4D89-92CD-911615DE747AQ34509707-A2EA82E0-DD6E-46E3-AC5A-20BFE8A60E18Q34655565-040BC9BA-16A0-4E6A-8C10-81B31836CEA6Q34695320-077C621C-BD7F-4A37-9379-00F6AD6E3B26Q34800126-FA500618-DF42-4B6D-8E50-E15BD7CB2130Q34908066-89AE504C-B3AD-4F7F-9190-EA05FF59BE78Q35065639-E7991915-0996-45DF-B51C-184AE2B40C5DQ35087731-8C5D081C-6995-43F3-ACA0-FDECD977ADF9Q35213294-02AFFF11-110B-4F5B-B24D-A464583A5CB4Q35585661-2CB5F719-9876-49C7-905C-2943FB2056A5Q35869792-6195412C-9A1E-4675-87DB-89902F5E2B56Q36648747-F7A04E71-B8EB-49A8-9D9D-EB249F0EA261Q37278920-857D16E1-36DB-491E-B045-FC97D3E69B0EQ37280479-E04AF63F-2F9C-4277-88E4-66F26FE55F49Q38170369-F16CF274-AF6F-4779-AFDC-DEB486AE26C4Q39498096-33A90CEA-4D5E-4756-84A7-ED83972C0568Q41689708-0640E2A3-CB6C-484C-A771-BAA7328E1EDEQ43163224-C352FC63-8F9B-4FFE-AB2C-850165BDF4CAQ44268165-3A38B53D-B3B0-47C1-95B2-19ABC5FFDA39Q44456467-3F441654-6815-4505-8F4B-679A19D02FEFQ44556045-4AA33A3D-F14C-4151-97A0-E2C2733FC8E5Q46300666-3B586394-B843-4B09-9E04-AFD544219328Q58778548-3D83FB0A-1F03-4D31-AF79-6AC887EC74A4
P2860
Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Cooperativity between the prep ...... lucose-stimulated translation.
@en
Cooperativity between the prep ...... lucose-stimulated translation.
@nl
type
label
Cooperativity between the prep ...... lucose-stimulated translation.
@en
Cooperativity between the prep ...... lucose-stimulated translation.
@nl
prefLabel
Cooperativity between the prep ...... lucose-stimulated translation.
@en
Cooperativity between the prep ...... lucose-stimulated translation.
@nl
P2093
P2860
P356
P1476
Cooperativity between the prep ...... lucose-stimulated translation.
@en
P2093
P2860
P304
22553-22558
P356
10.1074/JBC.M011214200
P407
P577
2001-04-10T00:00:00Z