O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes
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Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytesCaenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauerO-GlcNAcylation and Metabolic Reprograming in CancerElevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin ResistanceInhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 AdipocytesKinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling PathwayAging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway ratsO-GlcNAc regulates FoxO activation in response to glucose.Targeted in vivo O-GlcNAc sensors reveal discrete compartment-specific dynamics during signal transduction.Protein kinase substrate identification on functional protein arraysO-linked N-acetylglucosamine modification of insulin receptor substrate-1 occurs in close proximity to multiple SH2 domain binding motifs.The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesisHigh glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: the possible role in the development of diabetic nephropathyThe role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy.Placental O-GlcNAc-transferase expression and interactions with the glucocorticoid receptor are sex specific and regulated by maternal corticosterone exposure in mice.Quantitative secretome and glycome of primary human adipocytes during insulin resistance.Glucosamine cardioprotection in perfused rat hearts associated with increased O-linked N-acetylglucosamine protein modification and altered p38 activation.A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance.dbOGAP - an integrated bioinformatics resource for protein O-GlcNAcylation.O-GlcNAc signaling: a metabolic link between diabetes and cancer?OGA inhibition by GlcNAc-selenazolineStructural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysisDisruption of O-GlcNAc Cycling in C. elegans Perturbs Nucleotide Sugar Pools and Complex Glycans.Multiple tissue-specific roles for the O-GlcNAc post-translational modification in the induction of and complications arising from type II diabetes.GALNT2 expression is reduced in patients with Type 2 diabetes: possible role of hyperglycemia.O-GlcNAcylation and Inflammation: A Vast Territory to ExplorePleiotropic and age-dependent effects of decreased protein modification by O-linked N-acetylglucosamine on pancreatic β-cell function and vascularization.Depletion of mitochondrial DNA stabilizes C1qTNF-related protein 6 mRNA in muscle cells.The roles of O-linked β-N-acetylglucosamine in cardiovascular physiology and disease.O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signalingDiverse regulation of AKT and GSK-3β by O-GlcNAcylation in various types of cells.Role of protein O-linked N-acetyl-glucosamine in mediating cell function and survival in the cardiovascular system.Akt1 is dynamically modified with O-GlcNAc following treatments with PUGNAc and insulin-like growth factor-1.Regulation of Akt signaling by O-GlcNAc in euglycemia.O-GlcNAc modification in diabetes and Alzheimer's disease.Type 2 Diabetes Dysregulates Glucose Metabolism in Cardiac Progenitor CellsDepletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability.Protein modification by O-linked GlcNAc reduces angiogenesis by inhibiting Akt activity in endothelial cellsO-GlcNAc cycling: implications for neurodegenerative disorders.The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways.
P2860
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P2860
O-GlcNAc modification on IRS-1 and Akt2 by PUGNAc inhibits their phosphorylation and induces insulin resistance in rat primary adipocytes
description
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
scientific journal article
@en
vedecký článok (publikovaný 2005/06/30)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/06/30)
@nl
наукова стаття, опублікована в червні 2005
@uk
مقالة علمية (نشرت في 30-6-2005)
@ar
name
O-GlcNAc modification on IRS-1 ...... ance in rat primary adipocytes
@ast
O-GlcNAc modification on IRS-1 ...... ance in rat primary adipocytes
@en
O-GlcNAc modification on IRS-1 ...... ance in rat primary adipocytes
@nl
type
label
O-GlcNAc modification on IRS-1 ...... ance in rat primary adipocytes
@ast
O-GlcNAc modification on IRS-1 ...... ance in rat primary adipocytes
@en
O-GlcNAc modification on IRS-1 ...... ance in rat primary adipocytes
@nl
prefLabel
O-GlcNAc modification on IRS-1 ...... ance in rat primary adipocytes
@ast
O-GlcNAc modification on IRS-1 ...... ance in rat primary adipocytes
@en
O-GlcNAc modification on IRS-1 ...... ance in rat primary adipocytes
@nl
P2093
P356
P1476
O-GlcNAc modification on IRS-1 ...... ance in rat primary adipocytes
@en
P2093
Seung Yoon Park
P2888
P304
P356
10.1038/EMM.2005.30
P577
2005-06-30T00:00:00Z
P5875
P6179
1041737525