Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation
about
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesionThe PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding moduleKank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamicsRegulation of small GTPases by GEFs, GAPs, and GDIsHuman Mena associates with Rac1 small GTPase in glioblastoma cell linesHigh-resolution structure of the Tiam1 PHn-CC-Ex domainMechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectorsMechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapsesRole of Abl kinase and the Wave2 signaling complex in HIV-1 entry at a post-hemifusion stepRegulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complexThe adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites.Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activationMembrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2.Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac.Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF) 1 and Ras-GRF2Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1).The role of fibroblast Tiam1 in tumor cell invasion and metastasisIdentification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4.RNAi mediated Tiam1 gene knockdown inhibits invasion of retinoblastomaRegulation of Neuronal Function by Ras-GRF Exchange Factors.The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells.Biological effects of RNAi targeted inhibiting Tiam1 gene expression on cholangiocarcinoma cells.The fibroblast Tiam1-osteopontin pathway modulates breast cancer invasion and metastasis.Small GTPase protein Rac-1 is activated with maturation and regulates cell morphology and function in chondrocytesDifferential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.Mechanical stretch decreases migration of alveolar epithelial cells through mechanisms involving Rac1 and Tiam1.Acquisition of contextual discrimination involves the appearance of a RAS-GRF1/p38 mitogen-activated protein (MAP) kinase-mediated signaling pathway that promotes long term potentiation (LTP)Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors.Inhibition and termination of physiological responses by GTPase activating proteins.BAR domain proteins regulate Rho GTPase signaling.Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.Deep brain stimulation of the subthalamic nucleus preferentially alters the translational profile of striatopallidal neurons in an animal model of Parkinson's disease.Induction of the Galpha(q) signaling cascade by the human immunodeficiency virus envelope is required for virus entry.Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization.GEFs: Dual regulation of Rac1 signaling.Age-dependent participation of Ras-GRF proteins in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons.Rho GTPase signaling complexes in cell migration and invasion.Rac is a dominant regulator of cadherin-directed actin assembly that is activated by adhesive ligation independently of Tiam1.
P2860
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P2860
Tiam1-IRSp53 complex formation directs specificity of rac-mediated actin cytoskeleton regulation
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Tiam1-IRSp53 complex formation ...... actin cytoskeleton regulation
@ast
Tiam1-IRSp53 complex formation ...... actin cytoskeleton regulation
@en
Tiam1-IRSp53 complex formation ...... actin cytoskeleton regulation
@nl
type
label
Tiam1-IRSp53 complex formation ...... actin cytoskeleton regulation
@ast
Tiam1-IRSp53 complex formation ...... actin cytoskeleton regulation
@en
Tiam1-IRSp53 complex formation ...... actin cytoskeleton regulation
@nl
prefLabel
Tiam1-IRSp53 complex formation ...... actin cytoskeleton regulation
@ast
Tiam1-IRSp53 complex formation ...... actin cytoskeleton regulation
@en
Tiam1-IRSp53 complex formation ...... actin cytoskeleton regulation
@nl
P2093
P2860
P3181
P1476
Tiam1-IRSp53 complex formation ...... actin cytoskeleton regulation
@en
P2093
Beth A Connolly
Jared Rice
Larry A Feig
Rachel J Buchsbaum
P2860
P304
P3181
P356
10.1128/MCB.25.11.4602-4614.2005
P407
P577
2005-06-01T00:00:00Z