AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane
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Deletion of Rab GAP AS160 modifies glucose uptake and GLUT4 translocation in primary skeletal muscles and adipocytes and impairs glucose homeostasis.Structural and population-based evaluations of TBC1D1 p.Arg125TrpLoss of AS160 Akt substrate causes Glut4 protein to accumulate in compartments that are primed for fusion in basal adipocytes.Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in AdipocytesThe Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.Sustained postexercise increases in AS160 Thr642 and Ser588 phosphorylation in skeletal muscle without sustained increases in kinase phosphorylationRegulatory mode shift of Tbc1d1 is required for acquisition of insulin-responsive GLUT4-trafficking activity.AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissuesGlut4 Is Sorted from a Rab10 GTPase-independent Constitutive Recycling Pathway into a Highly Insulin-responsive Rab10 GTPase-dependent Sequestration Pathway after Adipocyte Differentiation.Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4 translocation in rat adipocytes.The phytotoxin fusicoccin, a selective stabilizer of 14-3-3 interactions?14-3-3 binds p-5S;T642-AS160 (TBC1D4)Effect of troxerutin on insulin signaling molecules in the gastrocnemius muscle of high fat and sucrose-induced type-2 diabetic adult male rat.Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity
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AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane
description
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
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artículu científicu espublizáu en 2011
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im Mai 2011 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 2011/05/13)
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vědecký článek publikovaný v roce 2011
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wetenschappelijk artikel (gepubliceerd op 2011/05/13)
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наукова стаття, опублікована в травні 2011
@uk
name
AS160 phosphotyrosine-binding ...... usion with the plasma membrane
@ast
AS160 phosphotyrosine-binding ...... usion with the plasma membrane
@en
AS160 phosphotyrosine-binding ...... usion with the plasma membrane
@nl
type
label
AS160 phosphotyrosine-binding ...... usion with the plasma membrane
@ast
AS160 phosphotyrosine-binding ...... usion with the plasma membrane
@en
AS160 phosphotyrosine-binding ...... usion with the plasma membrane
@nl
prefLabel
AS160 phosphotyrosine-binding ...... usion with the plasma membrane
@ast
AS160 phosphotyrosine-binding ...... usion with the plasma membrane
@en
AS160 phosphotyrosine-binding ...... usion with the plasma membrane
@nl
P2860
P356
P1476
AS160 phosphotyrosine-binding ...... usion with the plasma membrane
@en
P2093
Beverley A Murrow
Judith D Richardson
P2860
P304
16574-16582
P356
10.1074/JBC.M111.226092
P407
P577
2011-03-17T00:00:00Z