Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice
about
Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotesDefective forebrain development in mice lacking gp330/megalin.Complexity of vitamin E metabolismHow Useful Are Monogenic Rodent Models for the Study of Human Non-Alcoholic Fatty Liver Disease?Familial hypobetalipoproteinemia: a reviewapo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotesA targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglyceridesA novel functional role for apolipoprotein B in male infertility in heterozygous apolipoprotein B knockout miceA gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B geneConcomitant inactivation of foxo3a and fancc or fancd2 reveals a two-tier protection from oxidative stress-induced hydrocephalusDual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob geneHepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying alleleIn vivo MRS measurement of liver lipid levels in mice.Deficient Vitamin E Uptake During Development Impairs Neural Tube Closure in Mice Lacking Lipoprotein Receptor SR-BI.Human luteinized granulosa cells secrete apoB100-containing lipoproteins.Does dietary folic acid supplementation in mouse NTD models affect neural tube development or gamete preference at fertilization?Core fucosylation is required for midline patterning during zebrafish development.The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols.Interaction between SCO-spondin and low density lipoproteins from embryonic cerebrospinal fluid modulates their roles in early neurogenesis.Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation.A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes.Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism.Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.From sugar to fat: How the transcription factor XBP1 regulates hepatic lipogenesis.Neural tube defects and abnormal brain development in F52-deficient mice.Potential biomarkers in psychiatry: focus on the cholesterol system.The role of maternal-fetal cholesterol transport in early fetal life: current insights.Insights from human congenital disorders of intestinal lipid metabolism.Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis.Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis.Chinese hamster ovary cells require the coexpression of microsomal triglyceride transfer protein and cholesterol 7alpha-hydroxylase for the assembly and secretion of apolipoprotein B-containing lipoproteins.Genetic landmarks for defects in mouse neural tube closure.Hypobetalipoproteinemic mice with a targeted apolipoprotein (Apo) B-27.6-specifying mutation: in vivo evidence for an important role of amino acids 1254-1744 of ApoB in lipid transport and metabolism of the apoB-containing lipoprotein.ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice.Apolipoprotein E and apolipoprotein B genotypes and risk for spina bifida.Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI.Deviant early pregnancy maternal triglyceride levels and increased risk of congenital anomalies: a prospective community-based cohort study.
P2860
Q24563247-DD0757AA-EC78-4BF5-AE7A-2FB41206BAE9Q24629015-B8AA2576-5030-49DE-9800-20D96EEA6B77Q28068513-1D8D6132-1935-40D8-9082-EC9E7012972BQ28074455-0B7818CA-A254-4F9A-AD89-50E956BCA0B6Q28183795-767AD89B-D17F-422A-AB85-43EE79A633BBQ28507091-110E4E6B-8104-42BC-A0EC-B2902930514CQ28507306-BC5D79F9-889B-4895-B349-ADD989537426Q28508453-BC1AB388-82A2-4E4D-8239-98CAE676733DQ28512923-5AE796BD-87BD-4409-9EB3-E1F1443EA102Q28512938-CBCF6D2F-C35E-4724-A46B-088C0134AB7CQ28589650-69F4B177-82EB-47D3-AD23-4969824FAC4BQ28593031-C316242A-2D16-4799-A09E-494152E48241Q30924323-73D17D8C-D45D-4FCF-9FEB-A6591B843D80Q33899448-32338773-DFEE-4A2B-82B9-B84B30F7AF90Q33993193-CD7F793A-25D3-4C25-95CC-6B13CBFB5739Q34116711-A6884F5C-335B-44C8-844A-F03ADDCF8314Q34390406-42B20F72-A0CF-4D14-AD7D-0AE98DB5F76FQ34715836-89D9D984-03C4-4A9D-AE4C-D13FE3AFF411Q35657220-E1677B83-5C0F-4B22-A4C9-8FBB91746477Q35711232-68D51AAA-A38E-4871-883F-E9F746BB0C6AQ35769011-450D9273-6167-4AFF-AC86-C61A67F9597DQ36212658-E219AE22-A0AA-446D-81DE-CDEF29338A5CQ36359516-B7CCEC1E-3427-451B-95D2-5CAC1880A7F8Q37519955-A06DB168-22C1-424A-8249-54D05C5E102AQ37596560-3A242D08-453F-4015-A3A1-6F9AC3920032Q37710371-58B8A2DB-FA1D-4164-81C2-2437195A7DC6Q37981261-E8934BA9-45F2-4B28-9D11-7A66B899CA9BQ38059934-05286A37-3EAD-48E8-97E0-85F8AEF830D3Q38267212-3AFBC44F-EE45-4CCE-913D-243A48AE493DQ38520583-B0850D7A-38E9-4BC9-BA13-C85203DF0145Q40236656-246A2F03-0401-4960-825A-23567B2CC639Q41616361-343C30A4-AE63-46B7-B1A1-86111B624C55Q41633803-F84B2A38-4C91-4ED0-B471-3EC5CCB30450Q43882521-0B50A941-4CFA-4019-9652-E44B7CF44959Q44138808-6016F2FE-C79D-45BF-AA97-7FE49CE60FEDQ44192504-C0B5BBBF-14AA-488A-8B23-FCFBC1F602B2Q45079531-55E797EC-E090-44B0-B7B1-ADEF078FD0D1Q51305109-96B51BC0-5978-4232-BDBB-D7EBA9B6058F
P2860
Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice
description
1993 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 1993
@ast
im März 1993 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1993/03/15)
@sk
vědecký článek publikovaný v roce 1993
@cs
wetenschappelijk artikel (gepubliceerd op 1993/03/15)
@nl
наукова стаття, опублікована в березні 1993
@uk
name
Targeted modification of the a ...... opmental abnormalities in mice
@ast
Targeted modification of the a ...... opmental abnormalities in mice
@en
Targeted modification of the a ...... opmental abnormalities in mice
@nl
type
label
Targeted modification of the a ...... opmental abnormalities in mice
@ast
Targeted modification of the a ...... opmental abnormalities in mice
@en
Targeted modification of the a ...... opmental abnormalities in mice
@nl
prefLabel
Targeted modification of the a ...... opmental abnormalities in mice
@ast
Targeted modification of the a ...... opmental abnormalities in mice
@en
Targeted modification of the a ...... opmental abnormalities in mice
@nl
P2093
P2860
P3181
P356
P1476
Targeted modification of the a ...... opmental abnormalities in mice
@en
P2093
P2860
P304
P3181
P356
10.1073/PNAS.90.6.2389
P407
P577
1993-03-01T00:00:00Z