Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis
about
Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmiasA connexin40 mutation associated with a malignant variant of progressive familial heart block type IAngiotensin II-induced sudden arrhythmic death and electrical remodelingConduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctionsElectrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical StudiesPhosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in miceRemoval of the cardiac troponin I N-terminal extension improves cardiac function in aged mice.Brugada syndrome with marked conduction disease: dual implications of a SCN5A mutation.C-reactive protein levels in the brugada syndrome.Whole-exome sequencing identifies Y1495X of SCN5A to be associated with familial conduction disease and sudden death.Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse modelEnhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: a pilot trial.Cardiac sodium channelopathies.Dual variation in SCN5A and CACNB2b underlies the development of cardiac conduction disease without Brugada syndrome.Defining a new paradigm for human arrhythmia syndromes: phenotypic manifestations of gene mutations in ion channel- and transporter-associated proteins.SCN5A mutations in Brugada syndrome are associated with increased cardiac dimensions and reduced contractility.Delayed conduction and its implications in murine Scn5a(+/-) hearts: independent and interacting effects of genotype, age, and sexFibrillin-1 genetic deficiency leads to pathological ageing of arteries in mice.Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy.Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo.Bringing home the bacon? The next step in cardiac sodium channelopathiesStriking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitroDiagnostic dilemmas: overlapping features of brugada syndrome and arrhythmogenic right ventricular cardiomyopathyReduced Na(+) and higher K(+) channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/- mice.Fibrosis, Connexin-43, and Conduction Abnormalities in the Brugada Syndrome.Frequency distribution analysis of activation times and regional fibrosis in murine Scn5a+/- hearts: the effects of ageing and sexCooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology.Sodium channel variants in heart disease: expanding horizons.Role of homeodomain-only protein in the cardiac conduction systemSplicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy.Knockin animal models of inherited arrhythmogenic diseases: what have we learned from them?The tight junction protein CAR regulates cardiac conduction and cell-cell communication.Elastin haploinsufficiency induces alternative aging processes in the aorta.Cardiac sodium channels and inherited electrophysiologic disorders: a pharmacogenetic overview.Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.Variants in the SCN5A Promoter Associated With Various Arrhythmia PhenotypesMouse Models of SCN5A-Related Cardiac ArrhythmiasPathophysiological Mechanisms of Sino-Atrial Dysfunction and Ventricular Conduction Disease Associated with SCN5A Deficiency: Insights from Mouse Models.Brugada syndrome: an update.Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects.
P2860
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P2860
Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis
description
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im April 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/04/12)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/04/12)
@nl
наукова стаття, опублікована у квітні 2005
@uk
مقالة علمية (نشرت في 12-4-2005)
@ar
name
Mouse model of SCN5A-linked he ...... lowing and myocardial fibrosis
@ast
Mouse model of SCN5A-linked he ...... lowing and myocardial fibrosis
@en
Mouse model of SCN5A-linked he ...... lowing and myocardial fibrosis
@nl
type
label
Mouse model of SCN5A-linked he ...... lowing and myocardial fibrosis
@ast
Mouse model of SCN5A-linked he ...... lowing and myocardial fibrosis
@en
Mouse model of SCN5A-linked he ...... lowing and myocardial fibrosis
@nl
prefLabel
Mouse model of SCN5A-linked he ...... lowing and myocardial fibrosis
@ast
Mouse model of SCN5A-linked he ...... lowing and myocardial fibrosis
@en
Mouse model of SCN5A-linked he ...... lowing and myocardial fibrosis
@nl
P2093
P50
P3181
P1433
P1476
Mouse model of SCN5A-linked he ...... lowing and myocardial fibrosis
@en
P2093
Andrew A. Grace
Anne Royer
Anne-Laure Léoni
Brigitte Escoubet
Catharine A. Goddard
Christine Richer
Céline Marionneau
Daniel Gros
Harold V. M. van Rijen
Jacques M. T. de Bakker
P304
P3181
P356
10.1161/01.CIR.0000160853.19867.61
P407
P577
2005-04-12T00:00:00Z