Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3 - Wikidata - wikimedia - TriplyDB

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

http://www.wikidata.org/entity/Q30448362

about

Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton Src kinase activation by direct interaction with the integrin beta cytoplasmic domain Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk Mechanism of Bruton's tyrosine kinase-mediated recruitment and regulation of TFII-I c-Src-dependent transcriptional activation of TFII-I Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3 GPVI and integrin alphaIIb beta3 signaling in platelets Involvement of Hic-5 in platelet activation: integrin alphaIIbbeta3-dependent tyrosine phosphorylation and association with proline-rich tyrosine kinase 2 Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption The CXC-chemokine CXCL4 interacts with integrins implicated in angiogenesis.Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo.The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.Syk protein-tyrosine kinase is involved in neuron-like differentiation of embryonal carcinoma P19 cells.The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.The Syk protein tyrosine kinase is essential for Fcgamma receptor signaling in macrophages and neutrophils Genetic evidence of a role for Lck in T-cell receptor function independent or downstream of ZAP-70/Syk protein tyrosine kinases.A unique insert in the linker domain of Syk is necessary for its function in immunoreceptor signalling.Minding the gaps to promote thrombus growth and stability GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.The tandem Src homology 2 domain of the Syk kinase: a molecular device that adapts to interphosphotyrosine distances The role of the adapter molecule SLP-76 in platelet function.Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation Dancing with multiple partners.The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling.Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.Contact-dependent signaling during the late events of platelet activation.Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors Targeting Syk as a treatment for allergic and autoimmune disorders.Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets.Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3 Integrin-mediated signals regulated by members of the rho family of GTPases.Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells.Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling.The SYK tyrosine kinase: a crucial player in diverse biological functions.Convergence of immunoreceptor and integrin signaling.Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering.

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P2860

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

http://www.wikidata.org/entity/Q30448362

description

1997 nî lūn-bûn

@nan

1997 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1997 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

1997年の論文

@ja

1997年論文

@yue

1997年論文

@zh-hant

1997年論文

@zh-hk

1997年論文

@zh-mo

1997年論文

@zh-tw

1997年论文

@wuu

name

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

@ast

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

@en

type

label

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

@ast

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

@en

prefLabel

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

@ast

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

@en

P1433

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P1433

The EMBO Journal

P1476

Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3

@en

P2093

J Gao

http://www.w3.org/2001/XMLSchema#string

J S Brugge

http://www.w3.org/2001/XMLSchema#string

K E Zoller

http://www.w3.org/2001/XMLSchema#string

M H Ginsberg

http://www.w3.org/2001/XMLSchema#string

S J Shattil

http://www.w3.org/2001/XMLSchema#string

P2860

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk

Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance

Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src

Identification of the site in the Syk protein tyrosine kinase that binds the SH2 domain of Lck

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets

Interaction of phosphorylated FcepsilonRIgamma immunoglobulin receptor tyrosine activation motif-based peptides with dual and single SH2 domains of p72syk. Assessment of binding parameters and real time binding kinetics

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

P304

6414-6425

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P31

scholarly article

P356

10.1093/EMBOJ/16.21.6414

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P407

P433

21

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P478

16

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P577

1997-11-01T00:00:00Z

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P5875

13877312

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P698

9351824

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P932

1170248

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