Female embryonic lethality in mice nullizygous for both Msh2 and p53
about
Genetic Stabilization by p53 Involves Growth Regulatory and Repair Pathwaysp53 in the DNA-Damage-Repair ProcessSex chromosomes and brain genderIncreased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair proteinSevere attenuation of the B cell immune response in Msh2-deficient miceSex chromosome complement affects social interactions in mice.The DNA repair genes XPB and XPD defend cells from retroviral infectionAltered spectra of hypermutation in DNA repair-deficient mice.Use of genetically engineered mice in drug discovery and development: wielding Occam's razor to prune the product portfolio.Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouseDisabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null backgroundWhat does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues?Programmed genetic instability: a tumor-permissive mechanism for maintaining the evolvability of higher species through methylation-dependent mutation of DNA repair genes in the male germ line.Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes.The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repairDNA substrate dependence of p53-mediated regulation of double-strand break repair.Association of p53 and MSH2 with recombinative repair complexes during S phase.A role for mismatch repair in control of DNA ploidy following DNA damage.p53 protects from replication-associated DNA double-strand breaks in mammalian cells.Mutations in Lyar and p53 are synergistically lethal in female mice.Fancm-deficient mice reveal unique features of Fanconi anemia complementation group M.Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background
P2860
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P2860
Female embryonic lethality in mice nullizygous for both Msh2 and p53
description
1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artículu científicu espublizáu en 1997
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im September 1997 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1997/09/01)
@sk
vědecký článek publikovaný v roce 1997
@cs
wetenschappelijk artikel (gepubliceerd op 1997/09/01)
@nl
наукова стаття, опублікована у вересні 1997
@uk
name
Female embryonic lethality in mice nullizygous for both Msh2 and p53
@ast
Female embryonic lethality in mice nullizygous for both Msh2 and p53
@en
Female embryonic lethality in mice nullizygous for both Msh2 and p53
@nl
type
label
Female embryonic lethality in mice nullizygous for both Msh2 and p53
@ast
Female embryonic lethality in mice nullizygous for both Msh2 and p53
@en
Female embryonic lethality in mice nullizygous for both Msh2 and p53
@nl
prefLabel
Female embryonic lethality in mice nullizygous for both Msh2 and p53
@ast
Female embryonic lethality in mice nullizygous for both Msh2 and p53
@en
Female embryonic lethality in mice nullizygous for both Msh2 and p53
@nl
P2093
P2860
P356
P1433
P1476
Female embryonic lethality in mice nullizygous for both Msh2 and p53
@en
P2093
A. Cranston
A. Reitmair
J. Palazzo
P2860
P2888
P304
P356
10.1038/NG0997-114
P407
P577
1997-09-01T00:00:00Z
P6179
1039304708