Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
about
The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functionsAurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppressionUbiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activationHow cells switch HIPK2 on and offThe human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4The Axin1 scaffold protein promotes formation of a degradation complex for c-MycAxin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.p53 mediates the negative regulation of MDM2 by orphan receptor TR3Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitmentOverlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.Generation of Axin1 conditional mutant miceAxin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functionsProtein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signalingMalleable ribonucleoprotein machine: protein intrinsic disorder in the Saccharomyces cerevisiae spliceosome.The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2)HIPK2: a multitalented partner for transcription factors in DNA damage response and development.Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners.Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.Human Sarcoma growth is sensitive to small-molecule mediated AXIN stabilization.Axin downregulates TCF-4 transcription via beta-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells.Mechanistic insight into Myc stabilization in breast cancer involving aberrant Axin1 expressionAxin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cellsHomeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response.Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes.Intrinsic disorder in scaffold proteins: getting more from lessMDM2 Inhibits Axin-Induced p53 Activation Independently of its E3 Ligase Activity.Regulation of Wnt/beta-catenin signaling by protein kinasesHigh-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2.RAD6 regulates the dosage of p53 by a combination of transcriptional and posttranscriptional mechanismsRHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect.N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents.The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocationA conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesisAutophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death.Detection of TP53 R249 Mutation in Iranian Patients with Pancreatic CancerWnt signalling and the control of cellular metabolism.Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.A novel oncoprotein Pirh2: rising from the shadow of MDM2.Toward a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment.
P2860
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P2860
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
description
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2004
@ast
im November 2004 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2004/11/24)
@sk
vědecký článek publikovaný v roce 2004
@cs
wetenschappelijk artikel (gepubliceerd op 2004/11/24)
@nl
наукова стаття, опублікована в листопаді 2004
@uk
مقالة علمية (نشرت في 24-11-2004)
@ar
name
Axin stimulates p53 functions ...... h multimeric complex formation
@ast
Axin stimulates p53 functions ...... h multimeric complex formation
@en
Axin stimulates p53 functions ...... h multimeric complex formation
@nl
type
label
Axin stimulates p53 functions ...... h multimeric complex formation
@ast
Axin stimulates p53 functions ...... h multimeric complex formation
@en
Axin stimulates p53 functions ...... h multimeric complex formation
@nl
prefLabel
Axin stimulates p53 functions ...... h multimeric complex formation
@ast
Axin stimulates p53 functions ...... h multimeric complex formation
@en
Axin stimulates p53 functions ...... h multimeric complex formation
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Axin stimulates p53 functions ...... h multimeric complex formation
@en
P2093
Hai-Meng Zhou
Hongliang Rui
Jiahuai Han
Po-Yan Cheung
Sheng-Cai Lin
Shuyong Lin
Yanning Rui
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7600475
P407
P50
P577
2004-11-04T00:00:00Z