Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease.
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Laforin, the most common protein mutated in Lafora disease, regulates autophagyLaforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cellsAutophagy and neurodegenerationLoss of GABAergic cortical neurons underlies the neuropathology of Lafora diseaseTau, prions and Aβ: the triad of neurodegeneration.The laforin-malin complex negatively regulates glycogen synthesis by modulating cellular glucose uptake via glucose transporters.Ontogeny of Lafora bodies and neurocytoskeleton changes in Laforin-deficient mice.Laforin, a protein with many faces: glucan phosphatase, adapter protein, et alii.Laforin prevents stress-induced polyglucosan body formation and Lafora disease progression in neurons.Glycogen and its metabolism: some new developments and old themes.Inhibiting glycogen synthesis prevents Lafora disease in a mouse model.Activation of serum/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease.Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tagPhenotype variations in Lafora progressive myoclonus epilepsy: possible involvement of genetic modifiers?Pathogenesis of Lafora Disease: Transition of Soluble Glycogen to Insoluble Polyglucosan.A novel rabbit monoclonal antibody platform to dissect the diverse repertoire of antibody epitopes for HIV-1 Env immunogen design.Regulation of cell survival mechanisms in Alzheimer's disease by glycogen synthase kinase-3The Laforin-like dual-specificity phosphatase SEX4 from Arabidopsis hydrolyzes both C6- and C3-phosphate esters introduced by starch-related dikinases and thereby affects phase transition of alpha-glucans.Sodium selenate treatment improves symptoms and seizure susceptibility in a malin-deficient mouse model of Lafora disease.Dysfunctions in endosomal-lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease.
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P2860
Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 June 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Hyperphosphorylation and aggre ...... imal model for Lafora disease.
@en
Hyperphosphorylation and aggre ...... imal model for Lafora disease.
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type
label
Hyperphosphorylation and aggre ...... imal model for Lafora disease.
@en
Hyperphosphorylation and aggre ...... imal model for Lafora disease.
@nl
prefLabel
Hyperphosphorylation and aggre ...... imal model for Lafora disease.
@en
Hyperphosphorylation and aggre ...... imal model for Lafora disease.
@nl
P2860
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P356
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Hyperphosphorylation and aggre ...... nimal model for Lafora disease
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P2093
Subramaniam Ganesh
P2860
P304
22657-22663
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10.1074/JBC.M109.009688
P407
P577
2009-06-19T00:00:00Z