TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle
about
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+Regulation of ion channels by pyridine nucleotidesReconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+Domain assembly of NAADP-gated two-pore channelsExpression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cellsTwo-pore channels (TPCs): current controversiesConvergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinasesAcidic NAADP-sensitive calcium stores in the endothelium: agonist-specific recruitment and role in regulating blood pressure.Lysosomal physiology.VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.Function and dysfunction of two-pore channels.Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke.Two-Pore Channels: Lessons from Mutant Mouse ModelsTwo pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells.Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis.Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.Identification of two-pore channel 2 as a novel regulator of osteoclastogenesis.Intracellular sphingosine releases calcium from lysosomes.Nicotinic acid adenine dinucleotide phosphate (NAADP) activates global and heterogeneous local Ca2+ signals from NAADP- and ryanodine receptor-gated Ca2+ stores in pulmonary arterial myocytesTwo-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions.NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.Physiological roles of NAADP-mediated Ca2+ signaling.Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease.Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization.Calcium signaling in membrane repair.TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.Two pore channel 2 (TPC2) inhibits autophagosomal-lysosomal fusion by alkalinizing lysosomal pH.Nicotinic acid adenine dinucleotide phosphate (NAADP) regulates autophagy in cultured astrocytesThe Molecular Basis for Ca2+ Signalling by NAADP: Two-Pore Channels in a Complex?Ca(2+) signals evoked by histamine H1 receptors are attenuated by activation of prostaglandin EP2 and EP4 receptors in human aortic smooth muscle cells.Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.Triggering of Ca2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?
P2860
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P2860
TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle
description
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2010
@ast
im August 2010 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2010/08/06)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/08/06)
@nl
наукова стаття, опублікована в серпні 2010
@uk
name
TPC2 proteins mediate nicotini ...... contractions of smooth muscle
@ast
TPC2 proteins mediate nicotini ...... contractions of smooth muscle
@en
TPC2 proteins mediate nicotini ...... contractions of smooth muscle
@nl
type
label
TPC2 proteins mediate nicotini ...... contractions of smooth muscle
@ast
TPC2 proteins mediate nicotini ...... contractions of smooth muscle
@en
TPC2 proteins mediate nicotini ...... contractions of smooth muscle
@nl
prefLabel
TPC2 proteins mediate nicotini ...... contractions of smooth muscle
@ast
TPC2 proteins mediate nicotini ...... contractions of smooth muscle
@en
TPC2 proteins mediate nicotini ...... contractions of smooth muscle
@nl
P2093
P2860
P356
P1476
TPC2 proteins mediate nicotini ...... contractions of smooth muscle
@en
P2093
Alison Brading
John Parrington
Kai-Ting Chuang
Margarida Ruas
Nezahat Tugba Durlu-Kandilci
P2860
P304
24925–24932
P356
10.1074/JBC.M110.129833
P407
P577
2010-08-06T00:00:00Z