Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases
about
Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibitionThe role of TRPMLs in endolysosomal trafficking and functionTwo-pore channels at the intersection of endolysosomal membrane trafficReconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+High susceptibility to fatty liver disease in two-pore channel 2-deficient miceExpression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cellsTPC: the NAADP discovery channel?Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thalianaThe phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infectionThe voltage-gated sodium channel TPC1 confers endolysosomal excitability.Two-Pore Channels and Parkinson's Disease: Where's the Link?Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis.Lysosomal physiology.VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.Function and dysfunction of two-pore channels.Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.Two-Pore Channels: Lessons from Mutant Mouse ModelsTwo-Pore Channels: Catalyzers of Endolysosomal Transport and Function.The human two-pore channel 1 is modulated by cytosolic and luminal calcium.The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentationOrganelle-specific subunit interactions of the vertebrate two-pore channel family.Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.Phosphoinositides regulate ion channels.Organellar channels and transporters.Genetic Variants of TPCN2 Associated with Type 2 Diabetes Risk in the Chinese Population.Both RyRs and TPCs are required for NAADP-induced intracellular Ca²⁺ releaseMetabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.Acidic Ca2+ stores in neurodegeneration.Intracellular sphingosine releases calcium from lysosomes.Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions.Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel.Ion transport in pigmentation.Organelle biogenesis and interorganellar connections: Better in contact than in isolation.A New Perspective of Lysosomal Cation Channel-Dependent Homeostasis in Alzheimer's Disease.Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.Poring over two-pore channel pore mutants.From contraction to gene expression: nanojunctions of the sarco/endoplasmic reticulum deliver site- and function-specific calcium signals.
P2860
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P2860
Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Convergent regulation of the l ...... ₂ and multiple protein kinases
@ast
Convergent regulation of the l ...... ₂ and multiple protein kinases
@en
Convergent regulation of the l ...... ₂ and multiple protein kinases
@nl
type
label
Convergent regulation of the l ...... ₂ and multiple protein kinases
@ast
Convergent regulation of the l ...... ₂ and multiple protein kinases
@en
Convergent regulation of the l ...... ₂ and multiple protein kinases
@nl
prefLabel
Convergent regulation of the l ...... ₂ and multiple protein kinases
@ast
Convergent regulation of the l ...... ₂ and multiple protein kinases
@en
Convergent regulation of the l ...... ₂ and multiple protein kinases
@nl
P2093
P2860
P3181
P356
P1433
P1476
Convergent regulation of the l ...... ₂ and multiple protein kinases
@en
P2093
Archana Jha
Eugen Brailoiu
Malini Ahuja
Shmuel Muallem
P2860
P304
P3181
P356
10.1002/EMBJ.201387035
P407
P50
P577
2014-02-05T00:00:00Z