Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases - Wikidata - wikimedia - TriplyDB

Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases

Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases

http://www.wikidata.org/entity/Q28307378

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Dysregulation of lysosomal morphology by pathogenic LRRK2 is corrected by TPC2 inhibition The role of TRPMLs in endolysosomal trafficking and function Two-pore channels at the intersection of endolysosomal membrane traffic Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+High susceptibility to fatty liver disease in two-pore channel 2-deficient mice Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells TPC: the NAADP discovery channel?Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection The voltage-gated sodium channel TPC1 confers endolysosomal excitability.Two-Pore Channels and Parkinson's Disease: Where's the Link?Naringenin Impairs Two-Pore Channel 2 Activity And Inhibits VEGF-Induced Angiogenesis.Lysosomal physiology.VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling.Function and dysfunction of two-pore channels.Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.Two-Pore Channels: Lessons from Mutant Mouse Models Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.The human two-pore channel 1 is modulated by cytosolic and luminal calcium.The Two-pore channel (TPC) interactome unmasks isoform-specific roles for TPCs in endolysosomal morphology and cell pigmentation Organelle-specific subunit interactions of the vertebrate two-pore channel family.Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.Phosphoinositides regulate ion channels.Organellar channels and transporters.Genetic Variants of TPCN2 Associated with Type 2 Diabetes Risk in the Chinese Population.Both RyRs and TPCs are required for NAADP-induced intracellular Ca²⁺ release Metabolic alterations derived from absence of Two-Pore Channel 1 at cardiac level.Acidic Ca2+ stores in neurodegeneration.Intracellular sphingosine releases calcium from lysosomes.Two-pore channels (TPCs): Novel voltage-gated ion channels with pleiotropic functions.Structural basis of dual Ca2+/pH regulation of the endolysosomal TRPML1 channel.Ion transport in pigmentation.Organelle biogenesis and interorganellar connections: Better in contact than in isolation.A New Perspective of Lysosomal Cation Channel-Dependent Homeostasis in Alzheimer's Disease.Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification.Poring over two-pore channel pore mutants.From contraction to gene expression: nanojunctions of the sarco/endoplasmic reticulum deliver site- and function-specific calcium signals.

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Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases

http://www.wikidata.org/entity/Q28307378

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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Convergent regulation of the l ...... ₂ and multiple protein kinases

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Convergent regulation of the l ...... ₂ and multiple protein kinases

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Convergent regulation of the l ...... ₂ and multiple protein kinases

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Convergent regulation of the l ...... ₂ and multiple protein kinases

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Convergent regulation of the l ...... ₂ and multiple protein kinases

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Convergent regulation of the l ...... ₂ and multiple protein kinases

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The EMBO Journal

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Convergent regulation of the l ...... ₂ and multiple protein kinases

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Archana Jha

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Eugen Brailoiu

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Malini Ahuja

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Shmuel Muallem

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P2860

mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state

Essential requirement for two-pore channel 1 in NAADP-mediated calcium signaling

NAADP mobilizes calcium from acidic organelles through two-pore channels

Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg

Photoaffinity labeling of nicotinic acid adenine dinucleotide phosphate (NAADP) targets in mammalian cells

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs

Membrane potential regulates nicotinic acid adenine dinucleotide phosphate (NAADP) dependence of the pH- and Ca2+-sensitive organellar two-pore channel TPC1

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes

Activation and inactivation of Ca2+ release by NAADP+

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501-511

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4630817

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10.1002/EMBJ.201387035

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5

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24502975

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3989630

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