Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context

Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context

Item
http://www.wikidata.org/entity/Q28588981
Polyglutamine expansion of huntingtin impairs its nuclear exportNucleocytoplasmic shuttling activity of ataxin-3.Translation of the prion protein mRNA is robust in astrocytes but does not amplify during reactive astrocytosis in the mouse brainCAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse.Assessment of locomotion in chlorine exposed mice by computer vision and neural networks.Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtinTranscriptional signatures in Huntington's disease.Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent mannerFrom pathways to targets: understanding the mechanisms behind polyglutamine disease.Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice.Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.Assessing mouse behaviour throughout the light/dark cycle using automated in-cage analysis tools.
P2860

Nucleocytoplasmic transport signals affect the age at onset of abnormalities in knock-in mice expressing polyglutamine within an ectopic protein context

Item
http://www.wikidata.org/entity/Q28588981
description
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Juli 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/07/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/07/01)
@nl
наукова стаття, опублікована в липні 2003
@uk
مقالة علمية (نشرت في يوليو 2003)
@ar
name
Nucleocytoplasmic transport si ...... hin an ectopic protein context
@ast
Nucleocytoplasmic transport si ...... hin an ectopic protein context
@en
Nucleocytoplasmic transport si ...... hin an ectopic protein context
@nl
type
label
Nucleocytoplasmic transport si ...... hin an ectopic protein context
@ast
Nucleocytoplasmic transport si ...... hin an ectopic protein context
@en
Nucleocytoplasmic transport si ...... hin an ectopic protein context
@nl
prefLabel
Nucleocytoplasmic transport si ...... hin an ectopic protein context
@ast
Nucleocytoplasmic transport si ...... hin an ectopic protein context
@en
Nucleocytoplasmic transport si ...... hin an ectopic protein context
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P50
P577
P698
P921
P356
P1433
P1476
Nucleocytoplasmic transport si ...... hin an ectopic protein context
@en
P2093
P304
P31
P356
P433
P478
P50
P577
P698
P921