Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development
about
The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phaseS phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain proteinHomeoproteins CDP and SATB1 interact: potential for tissue-specific regulationSpecific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114PU.1 as an essential activator for the expression of gp91(phox) gene in human peripheral neutrophils, monocytes, and B lymphocytesHepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domainGenetic ablation of the CDP/Cux protein C terminus results in hair cycle defects and reduced male fertilityAcceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1Asynchronous expression of the homeodomain protein CUX1 in Sertoli cells and spermatids during spermatogenesis in mice.Cux/CDP homeoprotein is a component of NF-muNR and represses the immunoglobulin heavy chain intronic enhancer by antagonizing the bright transcription activatorCDP is a repressor of mouse mammary tumor virus expression in the mammary gland.CDP binding to multiple sites in the mouse mammary tumor virus long terminal repeat suppresses basal and glucocorticoid-induced transcriptionThe homeobox gene cut interacts genetically with the homeotic genes proboscipedia and AntennapediaDifferentiation-induced cleavage of Cutl1/CDP generates a novel dominant-negative isoform that regulates mammary gene expression.Hepatomegaly in transgenic mice expressing the homeobox gene Cux-1Sequence-specific DNA binding of individual cut repeats of the human CCAAT displacement/cut homeodomain protein.Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia.CCAAT displacement protein, a regulator of differentiation-specific gene expression, binds a negative regulatory element within the 5' end of the human papillomavirus type 6 long control region.Interaction of the CCAAT displacement protein with shared regulatory elements required for transcription of paired histone genes.Regulation of Gax homeobox gene transcription by a combination of positive factors including myocyte-specific enhancer factor 2Quantitative discrimination of MEF2 sites.The human cut homeodomain protein can repress gene expression by two distinct mechanisms: active repression and competition for binding site occupancy.DNA-binding specificity of the cut repeats from the human cut-like proteinThe matrix attachment region-binding protein SATB1 participates in negative regulation of tissue-specific gene expression.The human cut homeodomain protein represses transcription from the c-myc promoter.The homeodomain protein Cux1 interacts with Grg4 to repress p27 kip1 expression during kidney development.Regulation of cell proliferation and differentiation in the kidney.Antisense oligonucleotides to Cux-1, a Cut-related homeobox gene, cause increased apoptosis in mouse embryonic kidney culturesOnecut transcription factors in development and disease.CCAAT displacement protein binds to and negatively regulates human papillomavirus type 6 E6, E7, and E1 promoters.Yin yang 1 negatively regulates the differentiation-specific E1 promoter of human papillomavirus type 6
P2860
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P2860
Clox, a mammalian homeobox gene related to Drosophila cut, encodes DNA-binding regulatory proteins differentially expressed during development
description
1992 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1992
@ast
im Oktober 1992 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 1992/10/01)
@sk
vědecký článek publikovaný v roce 1992
@cs
wetenschappelijk artikel (gepubliceerd op 1992/10/01)
@nl
наукова стаття, опублікована в жовтні 1992
@uk
مقالة علمية (نشرت في أكتوبر 1992)
@ar
name
Clox, a mammalian homeobox gen ...... y expressed during development
@ast
Clox, a mammalian homeobox gen ...... y expressed during development
@en
Clox, a mammalian homeobox gen ...... y expressed during development
@nl
type
label
Clox, a mammalian homeobox gen ...... y expressed during development
@ast
Clox, a mammalian homeobox gen ...... y expressed during development
@en
Clox, a mammalian homeobox gen ...... y expressed during development
@nl
prefLabel
Clox, a mammalian homeobox gen ...... y expressed during development
@ast
Clox, a mammalian homeobox gen ...... y expressed during development
@en
Clox, a mammalian homeobox gen ...... y expressed during development
@nl
P2093
P1433
P1476
Clox, a mammalian homeobox gen ...... y expressed during development
@en
P2093
B. Nadal-Ginard
V. Mahdavi
P304
P407
P577
1992-10-01T00:00:00Z