Activation of GCN2 in UV-irradiated cells inhibits translation
about
Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2Nuclear relocalisation of cytoplasmic poly(A)-binding proteins PABP1 and PABP4 in response to UV irradiation reveals mRNA-dependent export of metazoan PABPsFibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathwaysThe roles of nitric oxide synthase and eIF2alpha kinases in regulation of cell cycle upon UVB-irradiationA novel checkpoint mechanism regulating the G1/S transitionModulation of translation and induction of autophagy by bacterial exoproductsAmino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TORThe structure of the PERK kinase domain suggests the mechanism for its activationCrystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and MammalsA common polymorphism in the 5' UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.Ultraviolet germicidal irradiation and its effects on elemental distributions in mouse embryonic fibroblast cells in x-ray fluorescence microanalysisActivating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress responseAntiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA virusesIMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowthTranslational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory.A subunit of eukaryotic translation initiation factor 2α-phosphatase (CreP/PPP1R15B) regulates membrane traffic.Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.Differential signaling circuits in regulation of ultraviolet C light-induced early- and late-phase activation of NF-κB.Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response.Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2.GCN2 has inhibitory effect on human immunodeficiency virus-1 protein synthesis and is cleaved upon viral infectionTranslational repression by RNA-binding protein TIARDouble-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis.Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation.Failure of amino acid homeostasis causes cell death following proteasome inhibition.GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat.Stimulators of translation identified during a small molecule screening campaigneIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.UVC-induced stress granules in mammalian cellsQuantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.Phosphorylation of eIF2α via the general control kinase, GCN2, modulates the ability of renal medullary cells to survive high urea stress.Dual role of methionyl-tRNA synthetase in the regulation of translation and tumor suppressor activity of aminoacyl-tRNA synthetase-interacting multifunctional protein-3DNA Damage Regulates Translation through β-TRCP Targeting of CRePIncreased susceptibility to DNA virus infection in mice with a GCN2 mutationNucleofection induces transient eIF2α phosphorylation by GCN2 and PERK.Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response.Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress ResponseRibosome profiling reveals an important role for translational control in circadian gene expressionTranslation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5' short ORFsStress-induced inhibition of translation independently of eIF2α phosphorylation.
P2860
Q24293501-CECFBAB1-E577-443A-833D-BECF808F8BDBQ24338494-6E2A497B-62EB-4558-90B0-C50755555D0EQ24531428-4EE5D49C-87E6-4944-A3DD-A1517CAA1E3BQ24632308-F22D30BD-81B5-4111-8DF3-420D3B47D92DQ24680505-D78FC5D2-DC19-4F87-BD9D-1BC277B1060DQ27000440-C474DEB6-E848-4FCD-891A-CC650BE821A7Q27001717-D6EA90A5-2889-4880-8BB2-33C4FCE97B93Q27667715-CEAAF6B2-440F-4609-BA9B-AE41D4B5619DQ27683181-F17239F3-20CD-490E-83FB-37029B0F152BQ27853206-D91E2321-39F1-491F-A195-345807E7595CQ28388368-A5D82B7D-E288-429E-8843-F6ECB88C54EAQ28508156-AA36DD3C-2254-466A-92A0-C26984E03761Q28586515-DF000C43-02EF-49D7-BB61-F4FD11758D3BQ28594198-74C6CE67-2462-466A-B45A-BB2968215FADQ30429927-1CCC8950-1C24-4A25-8270-0663A999DB64Q30525662-80F8BC20-4B50-4277-B740-9580A21849A4Q33447106-B8CF96CB-CABE-4898-806A-3DF174825B32Q34145906-B2C51F77-BD89-4F38-95B9-5AE73FE4C27FQ34236755-79D3A02B-77C5-479C-974F-28101AB7EA7AQ34427458-EA2AF891-0C80-4163-A886-BBF8C9F089D8Q34460393-02F6903C-136C-437E-994E-38B9557854FDQ34520016-F8B05D56-27EB-4949-8C75-23D7FD7B64BFQ34529304-89104C4E-A340-4D71-AA8D-074CE555EDF9Q34635166-616DED18-6200-46BB-A25E-BD00B022632BQ34642317-22D73C8F-684F-43C5-AA1D-7D2FBE649551Q35018430-DEA69A51-82D9-4D7A-BAE1-2A4DDC428D22Q35090040-1B5BE42F-FF2B-4209-A5A4-CEA8FF13EAB3Q35209983-592CFB1F-2FC9-41E1-9DB8-F30A827B65A6Q35435960-D25EF977-A03C-44E3-A486-622D1EE103FFQ35497627-26D1D672-8873-4F09-9109-BBDFA698BE4CQ35601609-B15C7758-65DC-48BA-89FB-B7C13E4C7A1AQ35621172-70CE1B78-4B79-417C-B39F-55E7DCFAB69EQ35668793-FBA2064E-C0DA-44FC-BA81-77B2FF6A4C26Q35689654-104529AD-6540-40E0-8426-F3CDDB26A272Q35936953-3DFFEEC2-6ED9-483C-8AE8-FD54B2E36694Q36052441-46EB3E76-2684-48C5-AC62-284B89B6A0ACQ36054263-73D10848-AA1C-44C3-BC4B-DFDF80E99EF8Q36333697-9DAFE19D-7572-4DA8-9F0A-15A7EB6A96FDQ36341562-C36470DB-23E0-4FF6-987E-B01F3CE190FDQ36462460-EE66B022-1ED5-48FA-ACD4-22047F6AEEB4
P2860
Activation of GCN2 in UV-irradiated cells inhibits translation
description
2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2002
@ast
im August 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2002/08/06)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/08/06)
@nl
наукова стаття, опублікована в серпні 2002
@uk
مقالة علمية (نشرت في 6-8-2002)
@ar
name
Activation of GCN2 in UV-irradiated cells inhibits translation
@ast
Activation of GCN2 in UV-irradiated cells inhibits translation
@en
Activation of GCN2 in UV-irradiated cells inhibits translation
@nl
type
label
Activation of GCN2 in UV-irradiated cells inhibits translation
@ast
Activation of GCN2 in UV-irradiated cells inhibits translation
@en
Activation of GCN2 in UV-irradiated cells inhibits translation
@nl
prefLabel
Activation of GCN2 in UV-irradiated cells inhibits translation
@ast
Activation of GCN2 in UV-irradiated cells inhibits translation
@en
Activation of GCN2 in UV-irradiated cells inhibits translation
@nl
P2093
P50
P3181
P1433
P1476
Activation of GCN2 in UV-irradiated cells inhibits translation
@en
P2093
Brian Raught
Donalyn Scheuner
Heather P. Harding
Juan Jose Berlanga
Randal J. Kaufman
P304
P3181
P356
10.1016/S0960-9822(02)01037-0
P407
P577
2002-08-06T00:00:00Z